Timofticiuc Iosif-Aliodor, Dragosloveanu Serban, Caruntu Ana, Scheau Andreea-Elena, Badarau Ioana Anca, Garofil Nicolae Dragos, Didilescu Andreea Cristiana, Caruntu Constantin, Scheau Cristian
Department of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Orthopaedics and Traumatology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
J Funct Biomater. 2024 Dec 19;15(12):383. doi: 10.3390/jfb15120383.
With the development of 3D bioprinting and the creation of innovative biocompatible materials, several new approaches have brought advantages to patients and surgical teams. Increasingly more bone defects are now treated using 3D-bioprinted prostheses and implementing new solutions relies on the ability of engineers and medical teams to identify methods of anchoring 3D-printed prostheses and to reveal the potential influence of bioactive materials on surrounding tissues. In this paper, we described why limb salvage surgery based on 3D bioprinting is a reliable and effective alternative to amputations, and why this approach is considered the new standard in modern medicine. The preliminary results of 3D bioprinting in one of the most challenging fields in surgery are promising for the future of machine-based medicine, but also for the possibility of replacing various parts from the human body with bioactive-based constructs. In addition, besides the materials and constructs that are already tested and applied in the human body, we also reviewed bioactive materials undergoing in vitro or in vivo testing with great potential for human applications in the near future. Also, we explored the recent advancements in clinically available 3D-bioprinted constructs and their relevance in this field.
随着3D生物打印技术的发展以及新型生物相容性材料的研发，一些新方法给患者和手术团队带来了诸多益处。如今，越来越多的骨缺损采用3D生物打印假体进行治疗，而实施新的解决方案依赖于工程师和医疗团队识别3D打印假体固定方法以及揭示生物活性材料对周围组织潜在影响的能力。在本文中，我们阐述了为何基于3D生物打印的保肢手术是截肢手术可靠且有效的替代方案，以及为何这种方法被视为现代医学的新标准。3D生物打印在外科手术最具挑战性的领域之一所取得的初步成果，不仅为基于机器的医学未来带来了希望，也为用基于生物活性的构建体替换人体各个部位提供了可能。此外，除了已经在人体中进行测试和应用的材料与构建体，我们还综述了正在进行体外或体内测试、在不久的将来极有可能应用于人体的生物活性材料。同时，我们还探讨了临床可用的3D生物打印构建体的最新进展及其在该领域的相关性。
