Swati Kumari, Agrawal Kirti, Raj Sibi, Kumar Rajeev, Prakash Anand, Kumar Dhruv
Department of Biotechnology, School of Life Science, Mahatma Gandhi Central University, Motihari, Bihar, India.
School of Health Sciences and Technology (SoHST), UPES University, Dehradun, India.
Med Res Rev. 2023 May;43(3):441-463. doi: 10.1002/med.21930. Epub 2022 Oct 7.
Brain tumors are most often diagnosed with solid neoplasms and are the primary reason for cancer-related deaths in both children and adults worldwide. With recent developments in the progression of novel targeted chemotherapies, the prognosis of malignant glioma remains dismal. However, the high recurrence rate and high mortality rate remain unresolved and are closely linked to the biological features of cancer stem cells (CSCs). Research on tumor biology has reached a new age with more understanding of CSC features. CSCs, a subpopulation of whole tumor cells, are now regarded as candidate therapeutic targets. Therefore, in the diagnosis and treatment of tumors, recognizing the biological properties of CSCs is of considerable significance. Here, we have discussed the concept of CSCs and their significant role in brain cancer growth and propagation. We have also discussed personalized therapeutic development and immunotherapies for brain cancer by specifically targeting CSCs.
脑肿瘤最常被诊断为实体瘤，并且是全球儿童和成人癌症相关死亡的主要原因。随着新型靶向化疗进展方面的最新发展，恶性胶质瘤的预后仍然很差。然而，高复发率和高死亡率仍未得到解决，并且与癌症干细胞（CSCs）的生物学特性密切相关。随着对CSCs特性有了更多了解，肿瘤生物学研究进入了一个新时代。CSCs作为整个肿瘤细胞的一个亚群，现在被视为候选治疗靶点。因此，在肿瘤的诊断和治疗中，认识CSCs的生物学特性具有相当重要的意义。在此，我们讨论了CSCs的概念及其在脑癌生长和扩散中的重要作用。我们还讨论了通过特异性靶向CSCs的脑癌个性化治疗发展和免疫疗法。
