School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China.
Chem Commun (Camb). 2022 Oct 25;58(85):11965-11968. doi: 10.1039/d2cc03590a.
We report that phosphorylation of gasdermin D (GSDMD)-NT, cleaved by inflammatory caspases, could inhibit pyroptosis. Phosphatase 1 (PP1) is responsible for the regulation of GSDMD phosphorylation and the capacity of GSDMD to induce cell death. Our findings reveal a critical regulatory mechanism as it provides insight into pyroptosis processes.
我们报告称，炎性半胱天冬酶切割的 Gasdermin D（GSDMD）-NT 的磷酸化可以抑制细胞焦亡。磷酸酶 1（PP1）负责 GSDMD 磷酸化的调节以及 GSDMD 诱导细胞死亡的能力。我们的发现揭示了一个关键的调控机制，为细胞焦亡过程提供了新的见解。
