蛋白磷酸酶 1 调节天冬氨酸半胱氨酸酶蛋白水解酶 D 的磷酸化和细胞焦亡。
Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis.
机构信息
School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China.
出版信息
Chem Commun (Camb). 2022 Oct 25;58(85):11965-11968. doi: 10.1039/d2cc03590a.
PMID:36205355
Abstract
We report that phosphorylation of gasdermin D (GSDMD)-NT, cleaved by inflammatory caspases, could inhibit pyroptosis. Phosphatase 1 (PP1) is responsible for the regulation of GSDMD phosphorylation and the capacity of GSDMD to induce cell death. Our findings reveal a critical regulatory mechanism as it provides insight into pyroptosis processes.
摘要
我们报告称，炎性半胱天冬酶切割的 Gasdermin D（GSDMD）-NT 的磷酸化可以抑制细胞焦亡。磷酸酶 1（PP1）负责 GSDMD 磷酸化的调节以及 GSDMD 诱导细胞死亡的能力。我们的发现揭示了一个关键的调控机制，为细胞焦亡过程提供了新的见解。
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