Hu Pengwei, Guo Lin, Zhao Lulu, Yang Chao, Xia Wujiong
State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
Org Lett. 2022 Oct 21;24(41):7583-7588. doi: 10.1021/acs.orglett.2c02976. Epub 2022 Oct 7.
An intermolecular alkene dicarbofunctionalization via electrochemical reduction that combines alkyl and aryl iodides with styrene derivatives was herein reported. The multicomponent reaction exhibited several synthetic advantages including simple operation, wide substrate scope, and convenience of amplification. Mechanistic investigations, including cyclic voltammetry (CV), electron paramagnetic resonance (EPR), and radical trapping reactions, support the electrochemical nickel catalytic cycle and formation of alkyl radical species from alkyl iodides.
本文报道了一种通过电化学还原实现的分子间烯烃双碳官能化反应，该反应将烷基碘化物和芳基碘化物与苯乙烯衍生物相结合。该多组分反应具有几个合成优势，包括操作简单、底物范围广以及易于放大。机理研究，包括循环伏安法（CV）、电子顺磁共振（EPR）和自由基捕获反应，支持电化学镍催化循环以及由烷基碘化物形成烷基自由基物种。
