生物样本采集、处理和存储的标准操作规程：来自急性胰腺炎中的 1 型糖尿病联盟。
Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Type 1 Diabetes in Acute Pancreatitis Consortium.
机构信息
From the Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL.
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA.
出版信息
Pancreas. 2022 Jul 1;51(6):593-597. doi: 10.1097/MPA.0000000000002077.
Differences in methods for biospecimen collection, processing, and storage can yield considerable variability and error. Therefore, best practices for standard operating procedures are critical for successful discovery, development, and validation of disease biomarkers. Here, we describe standard operating procedures developed for biospecimen collection during the DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) Study within the Type 1 Diabetes in Acute Pancreatitis Consortium. Notably, these protocols were developed using an integrative process based on prior consortium experience and with input from working groups with expertise in immunology, pancreatitis, and diabetes. Publication and adoption consistent biospecimen protocols will inform future studies and allow for better comparisons across different metabolic research efforts.
生物样本采集、处理和储存方法的差异可能会导致相当大的变异性和误差。因此，对于疾病生物标志物的成功发现、开发和验证，标准操作程序的最佳实践至关重要。在这里，我们描述了在 1 型糖尿病急性胰腺炎联盟内的 DREAM（与急性胰腺炎相关的糖尿病及其机制）研究中开发的用于生物样本采集的标准操作程序。值得注意的是，这些方案是使用基于先前联盟经验的综合过程制定的，并得到了在免疫学、胰腺炎和糖尿病方面具有专业知识的工作组的投入。发布和采用一致的生物样本协议将为未来的研究提供信息，并允许在不同的代谢研究工作中进行更好的比较。
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