在培养中维持长期造血的细胞在受到辐射后不具备再生能力。
[Cells that maintain long-term hematopoiesis in culture do not possess the capacity for regeneration following irradiation].
作者信息
Deriugina E I, Drize N I, Chertkov I L
出版信息
Biull Eksp Biol Med. 1987 Jul;104(7):96-9.
PMID:3620659
Abstract
It has been revealed by competitive repopulation assay that hemopoietic stem cells capable of supporting long-term hemopoiesis in the culture failed to regenerate after irradiation. 19 weeks after irradiation with 4 Gy the content of hemopoietic stem cells was 0.5% normal, while regeneration of CFUs was achieved up to subnormal level.
摘要
竞争性再增殖试验表明，在培养中能够支持长期造血的造血干细胞在照射后无法再生。用4 Gy照射19周后，造血干细胞的含量为正常水平的0.5%，而集落形成单位（CFU）的再生达到低于正常水平。
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