造血诱导微环境在辐射后造血再生中的作用
[The role of the hemopoiesis-inducing microenvironment in the postradiation regeneration of hemopoiesis].
作者信息
Agafonov V I, Dygaĭ A M, Shakhov V P, Gol'dberg E D
出版信息
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):111-6.
The dynamic of granulocytic macrophages and erythroid precursors content in bone marrow of CBA mice, irradiated by 2.0 Gy and the level of colony-stimulating and erythropoietic activities in supernatant of bone marrow myelocariocytes and blood serum were studied. The process of haemopoiesis regeneration was accompanied by increasing of the values of these indexes in bone marrow and peripheral blood. The treatment of bone marrow cells by monoclonal antibodies to Thy 1.2 antigens resulted in decreasing of myeloid precursors and diminishing of colony-stimulating activity of bone marrow cells supernatant.
研究了2.0 Gy照射的CBA小鼠骨髓中粒细胞巨噬细胞和红系前体细胞的动态变化，以及骨髓骨髓细胞上清液和血清中集落刺激活性和促红细胞生成活性水平。造血再生过程伴随着骨髓和外周血中这些指标值的增加。用抗Thy 1.2抗原单克隆抗体处理骨髓细胞导致髓系前体细胞减少和骨髓细胞上清液集落刺激活性降低。
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