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[使用负载阿司匹林的磁浓缩红细胞对犬颈动脉血栓形成进行局部预防]

[Local prevention of thrombosis in the dog carotid artery using magnetically concentrated erythrocytes loaded with aspirin].

作者信息

Orekhov A N, Beliaev A A, Orekhova N M, Samokhin G P, Ragimov S E

出版信息

Biull Eksp Biol Med. 1987 Aug;104(8):153-5.

PMID:3620667
Abstract

Thrombosis was induced in both canine carotid arteries by means of vascular wall flap inversion into their lumens. A red, completely occluding thrombus was formed inside the vessel 4 to 5 hours later. SmCo5 magnet was secured externally to one of the arteries. The constant magnetic field produced by the magnet had no influence on the clot formation. Autologous red cells loaded with ferromagnetic colloid compound and aspirin were administered intravenously through the hind paw route; total aspirin pool was 20 micrograms. Circulating magnetically-charged red cells have been earlier shown to concentrate in a canine artery in the constant magnet area. The administration of magnetically-charged red cells loaded with aspirin completely prevented arterial thrombosis in the magnet-supplied artery, having no detrimental effect on clot formation in the control artery.

摘要

通过将血管壁瓣翻转到犬类颈动脉管腔内,在两条颈动脉中诱发血栓形成。4至5小时后,血管内形成了一个红色的、完全阻塞的血栓。将SmCo5磁体固定在其中一条动脉的外部。磁体产生的恒定磁场对血栓形成没有影响。通过后爪途径静脉注射负载铁磁胶体化合物和阿司匹林的自体红细胞;阿司匹林总量为20微克。早期研究表明,循环中的带磁红细胞会集中在恒定磁场区域的犬类动脉中。注射负载阿司匹林的带磁红细胞可完全预防磁体作用动脉中的动脉血栓形成,而对对照动脉中的血栓形成没有不利影响。

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[Local prevention of thrombosis in the dog carotid artery using magnetically concentrated erythrocytes loaded with aspirin].[使用负载阿司匹林的磁浓缩红细胞对犬颈动脉血栓形成进行局部预防]
Biull Eksp Biol Med. 1987 Aug;104(8):153-5.
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