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通过对负载阿司匹林的红细胞进行磁靶向在动物动脉中局部预防血栓形成。

Local prevention of thrombosis in animal arteries by means of magnetic targeting of aspirin-loaded red cells.

作者信息

Orekhova N M, Akchurin R S, Belyaev A A, Smirnov M D, Ragimov S E, Orekhov A N

机构信息

Institute of Experimental Cardiology, USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.

出版信息

Thromb Res. 1990 Feb 15;57(4):611-6. doi: 10.1016/0049-3848(90)90078-q.

DOI:10.1016/0049-3848(90)90078-q
PMID:2326776
Abstract

Thrombosis was induced in 18 dog and 16 rabbit arteries by surgically inverting a vascular wall flap into its lumen. A completely occluding red thrombus was formed inside the vessel 4 to 5 hours later in 80% of cases. SmCo5 magnet was secured externally to one of the arteries. The constant magnetic field produced by the magnet had no influence on the clot formation. Autologous red cells loaded with ferromagnetic colloid compound and aspirin were administered intravenously and completely aborted arteriothrombosis on magnet-supplied side with no deterioratory effect on clot formation in the control artery.

摘要

通过手术将血管壁瓣翻转至管腔内,在18只犬和16只兔的动脉中诱导形成血栓。4至5小时后,80%的病例血管内形成了完全阻塞的红色血栓。将SmCo5磁体外部固定于其中一条动脉上。磁体产生的恒定磁场对血栓形成没有影响。静脉注射负载铁磁胶体化合物和阿司匹林的自体红细胞,磁体作用侧的动脉血栓形成完全中止,而对对照动脉的血栓形成没有恶化作用。

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Thromb Res. 1990 Feb 15;57(4):611-6. doi: 10.1016/0049-3848(90)90078-q.
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