情绪加工中的预期线索会改变无药物治疗的抑郁患者中联合显著性感觉运动功能网络的激活。
Anticipatory cues in emotional processing shift the activation of a combined salience sensorimotor functional network in drug-naïve depressed patients.
机构信息
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal; Clinical Academic Center - Braga, Braga, Portugal.
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal; Clinical Academic Center - Braga, Braga, Portugal; Psychological Neuroscience Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
出版信息
J Affect Disord. 2023 Jan 1;320:509-516. doi: 10.1016/j.jad.2022.09.165. Epub 2022 Oct 5.
BACKGROUND
Major depressive disorder is characterized by a large-scale brain network dysfunction, contributing to impairments in cognitive and affective functioning. Core regions of default mode, limbic and salience networks are also impaired in emotional processing and anticipation. This study aimed to explore default mode, salience, and limbic networks modulation during the processing of emotional stimuli with and without anticipatory cues in depression, and further investigate how these networks were functionally coupled with the rest of the brain.
METHODS
Twenty-one drug-naïve depressed patients and 15 matched controls were included in the study. All participants completed a psychological assessment and the affective pictures paradigm during an fMRI acquisition. Group independent component analysis and psychophysiological interactions analyses were performed.
RESULTS
A significant interaction between Cue, Valence and Group was found for the salience/sensorimotor network. When processing uncued emotional stimuli, patients showed increased activation of this network for negative vs. neutral pictures, whereas when anticipatory cues were displayed previously to the picture presentation, they invert this pattern of activation (hyperactivating the salience/sensorimotor network for positive vs. neutral pictures). Patients showed increased functional connectivity between the salience/sensorimotor network and the left amygdala as well as the right inferior parietal lobule compared to controls when processing uncued negative pictures.
LIMITATIONS
The sample size was modest, and the salience/sensorimotor network included regions not typically identified as part of salience network. Thus, this study should be replicated to further interpret the results.
CONCLUSIONS
Anticipatory cues shift the pattern of activation of the salience/sensorimotor network in drug-naïve depressed patients.
背景
重度抑郁症的特征是大脑网络的大规模功能障碍，导致认知和情感功能受损。默认模式、边缘和突显网络的核心区域在情绪处理和预期中也受到损害。本研究旨在探讨抑郁症患者在处理有和无预期提示的情绪刺激时默认模式、突显和边缘网络的调节作用，并进一步研究这些网络如何与大脑的其他部分进行功能连接。
方法
研究纳入了 21 名未经药物治疗的抑郁症患者和 15 名匹配的对照组。所有参与者在 fMRI 采集期间完成了心理评估和情感图片范式。进行了组独立成分分析和心理生理相互作用分析。
结果
在突显/感觉运动网络中，发现了线索、效价和组之间的显著交互作用。当处理无提示的情绪刺激时，患者在处理负性图片时表现出该网络的激活增加，而当在图片呈现前显示预期线索时，他们则反转了这种激活模式（在处理正性图片时突显/感觉运动网络过度激活）。与对照组相比，患者在处理无提示的负性图片时，突显/感觉运动网络与左侧杏仁核和右侧下顶叶之间的功能连接增加。
局限性
样本量不大，突显/感觉运动网络包括了通常不作为突显网络一部分的区域。因此，应该进行进一步的复制研究来解释结果。
结论
预期线索改变了未经药物治疗的抑郁症患者突显/感觉运动网络的激活模式。
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