Almdahl Ina S, Martinussen Liva J, Ousdal Olga Therese, Kraus Miroslawa, Sowa Piotr, Agartz Ingrid, Korsnes Maria S
Department of Old Age Psychiatry, Oslo University Hospital, Oslo, Norway.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Aging Ment Health. 2023 Sep-Oct;27(10):2043-2051. doi: 10.1080/13607863.2023.2179972. Epub 2023 Mar 13.
Late-life depression (LLD) is a common and debilitating disorder. Previously, resting-state studies have revealed abnormal functional connectivity (FC) of brain networks in LLD. Since LLD is associated with emotional-cognitive control deficits, the aim of this study was to compare FC of large-scale brain networks in older adults with and without a history of LLD during a cognitive control task with emotional stimuli.
Cross-sectional case-control study. Twenty participants diagnosed with LLD and 37 never-depressed adults 60-88 years of age underwent functional magnetic resonance imaging during an emotional Stroop task. Network-region-to-region FC was assessed with seed regions in the default mode, the frontoparietal, the dorsal attention, and the salience networks.
FC between salience and sensorimotor network regions and between salience and dorsal attention network regions were reduced in LLD patients compared to controls during the processing of incongruent emotional stimuli. The normally positive FC between these networks were negative in LLD patients and inversely correlated with vascular risk and white matter hyperintensities.
Emotional-cognitive control in LLD is associated with aberrant functional coupling between salience and other networks. This expands on the network-based LLD model and proposes the salience network as a target for future interventions.
老年期抑郁症（LLD）是一种常见且使人衰弱的疾病。此前，静息态研究已揭示LLD患者脑网络存在异常功能连接（FC）。由于LLD与情绪认知控制缺陷有关，本研究旨在比较有和没有LLD病史的老年人在一项带有情绪刺激的认知控制任务中大规模脑网络的FC。
横断面病例对照研究。20名被诊断为LLD的参与者和37名60 - 88岁未患过抑郁症的成年人在进行情绪Stroop任务期间接受了功能磁共振成像检查。使用默认模式、额顶叶、背侧注意和突显网络中的种子区域评估网络区域间的FC。
在处理不一致的情绪刺激时，与对照组相比，LLD患者突显网络与感觉运动网络区域之间以及突显网络与背侧注意网络区域之间的FC降低。这些网络之间通常呈正性的FC在LLD患者中呈负性，且与血管风险和白质高信号强度呈负相关。
LLD中的情绪认知控制与突显网络和其他网络之间异常的功能耦合有关。这扩展了基于网络的LLD模型，并提出突显网络作为未来干预的靶点。
