Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Respir Physiol Neurobiol. 2023 Jan;307:103976. doi: 10.1016/j.resp.2022.103976. Epub 2022 Oct 4.
In patients with cystic fibrosis (CF), thoracic morphology and its role in respiratory function is conditioned by anthropometric factors, as well as by pathological changes. While the lungs are continuously monitored, examinations of potential thoracic cage adaptations to the disease are rare. Hence, the aim of this study was to investigate thoracic configuration, and its correlation to spirometry measures over time.
In total, 344 high-resolution computed tomography (HRCT) examinations from 90 patients were assessed and analysed. Those results were subsequently related to spirometry measurements performed within the same period.
The cohort displayed no homogenous change in thoracic configuration over time, and correlation between thoracic area and spirometry variables could not be supported statistically.
Although the current study included a larger cohort of patients with CF compared to previous studies on thoracic morphology, no patient group-specific changes in thoracic configuration were revealed. Furthermore, no correlations between structural findings and functional respiratory measurements were found.
在囊性纤维化（CF）患者中，胸部形态及其对呼吸功能的影响受到人体测量因素以及病理变化的影响。虽然肺部一直在被监测，但对潜在的胸廓适应疾病的检查却很少见。因此，本研究旨在调查胸部结构及其与随时间变化的肺功能指标的相关性。
共评估了 90 名患者的 344 次高分辨率计算机断层扫描（HRCT）检查结果，并进行了分析。随后，将这些结果与同期进行的肺功能测量值相关联。
该队列的胸部形态随时间没有呈现出均匀的变化，并且无法从统计学上支持胸面积与肺功能指标之间的相关性。
尽管与先前关于胸廓形态的研究相比，本研究纳入了更多 CF 患者，但并未发现任何特定于患者群体的胸廓结构变化。此外，也未发现结构发现与功能呼吸测量之间存在相关性。
