Sinderholm Sposato Niklas, Bjerså Kristofer, Gilljam Marita, Lannefors Louise, Fagevik Olsén Monika
Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Eur Clin Respir J. 2024 May 8;11(1):2350206. doi: 10.1080/20018525.2024.2350206. eCollection 2024.
Respiration is an intricate interaction between visceral and musculoskeletal structures. In cystic fibrosis (CF), the airways and lungs are subject to progressive obstruction and destruction. However, knowledge about the musculoskeletal aspects of respiratory function and symptoms is still limited in this patient group.
In a cross-sectional comparative study, 21 adults with CF enrolled at the Gothenburg CF Centre were matched with 42 healthy controls. The two groups were examined and compared in terms of thoracic mobility, respiratory muscle strength, lung function, and musculoskeletal pain in accordance with a predefined protocol.
Significant differences were observed between the groups in the number of tender points, thoracic excursion, forced vital capacity (FVC), and forced expiratory volume (FEV). The CF group also demonstrated a tendency toward reduced function in other measurements, although these were not statistically significant.
This cross-sectional study revealed that people with CF have reduced thoracic mobility and an increased prevalence of muscular tender points, alongside decreased lung function, compared to healthy controls. These findings stress the need for greater emphasis on the often-overlooked musculoskeletal aspects of CF care, especially as people with CF are living longer and may require more musculoskeletal health support.
呼吸是内脏和肌肉骨骼结构之间复杂的相互作用。在囊性纤维化（CF）患者中，气道和肺部会逐渐受到阻塞和破坏。然而，关于该患者群体呼吸功能和症状的肌肉骨骼方面的知识仍然有限。
在一项横断面比较研究中，将哥德堡CF中心登记的21名成年CF患者与42名健康对照者进行匹配。根据预先确定的方案，对两组进行胸廓活动度、呼吸肌力量、肺功能和肌肉骨骼疼痛方面的检查和比较。
两组在压痛点数量、胸廓活动度、用力肺活量（FVC）和用力呼气量（FEV）方面存在显著差异。CF组在其他测量指标上也显示出功能下降的趋势，尽管这些差异无统计学意义。
这项横断面研究表明，与健康对照者相比，CF患者的胸廓活动度降低，肌肉压痛点患病率增加，同时肺功能下降。这些发现强调了在CF护理中需要更加重视经常被忽视的肌肉骨骼方面，特别是随着CF患者寿命延长，可能需要更多的肌肉骨骼健康支持。
