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Progesterone binding cyst protein (PBCP) in primary breast cancer: a new prognostic factor?

作者信息

Søreide J A, Lea O A, Kvinnsland S

出版信息

Breast Cancer Res Treat. 1987;9(2):123-8. doi: 10.1007/BF01807364.

DOI:10.1007/BF01807364
PMID:3620714
Abstract

Different secretory proteins have been evaluated as possible tumor markers in breast cancer. In this study progesterone binding cyst protein (PBCP) has been quantitated in breast tumor tissue. We report on a correlation of PBCP in cytosols of primary breast cancer, with known prognostic factors. A significant difference (p less than 0.001, Chi-square) in the frequency of PBCP-negative patients in clinical Stage I and Stage II is found. This was mainly attributed to a difference between T1 and T2 tumors, with less contribution from nodal status. A biological function of PBCP in breast cancer is not known. The distribution of PBCP in our patients has a close resemblance with expected number of node positive patients, suggesting that PBCP as a tumor marker may aid in providing prognostic information in breast cancer patients.

摘要

相似文献

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Progesterone binding cyst protein (PBCP) in primary breast cancer: a new prognostic factor?
Breast Cancer Res Treat. 1987;9(2):123-8. doi: 10.1007/BF01807364.
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引用本文的文献

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Expression and prognostic significance of apolipoprotein D in breast cancer.载脂蛋白D在乳腺癌中的表达及预后意义
Am J Pathol. 1994 Feb;144(2):310-20.
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Cytosol protein content and prognosis in operable breast cancer. Correlations with steroid hormone receptors and other prognostic factors.可手术乳腺癌的胞浆蛋白含量与预后。与类固醇激素受体及其他预后因素的相关性。
Breast Cancer Res Treat. 1991 Dec;20(1):25-32. doi: 10.1007/BF01833354.

本文引用的文献

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Biochemical correlates of morphologic differentiation in human breast cancer.人类乳腺癌形态学分化的生化关联
Surgery. 1982 Sep;92(3):443-9.
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The contribution of recent NSABP clinical trials of primary breast cancer therapy to an understanding of tumor biology--an overview of findings.近期NSABP原发性乳腺癌治疗临床试验对肿瘤生物学理解的贡献——研究结果概述
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国家乳腺癌手术辅助项目（方案编号4）的病理研究结果。X. 十年治疗失败的判别因素。
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Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features.乳腺大汗腺囊肿病液蛋白（GCDFP - 15）的免疫组织化学。顶泌汗腺上皮及具有顶泌汗腺特征的乳腺癌的一种标志物。
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Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.在含有抗体的琼脂糖凝胶中通过电泳对蛋白质进行定量估计。
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A method for producing specific antisera with small doses of immunogen.一种用小剂量免疫原制备特异性抗血清的方法。
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A specific progesterone-binding component of human breast cyst fluid.人乳腺囊肿液中的一种特异性孕酮结合成分。
J Biol Chem. 1973 Aug 25;248(16):5736-41.