• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Nomenclature of HBV core protein-targeting antivirals.靶向乙肝病毒核心蛋白的抗病毒药物的命名
Nat Rev Gastroenterol Hepatol. 2022 Dec;19(12):748-750. doi: 10.1038/s41575-022-00700-z.
2
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B.针对多功能 HBV 核心蛋白作为慢性乙型肝炎潜在治愈方法的研究。
Antiviral Res. 2020 Oct;182:104917. doi: 10.1016/j.antiviral.2020.104917. Epub 2020 Aug 17.
3
Hepatitis B virus gene expression in relation to virus replication and HBV-DNA integration. New concepts for antiviral therapy.乙型肝炎病毒基因表达与病毒复制及乙肝病毒脱氧核糖核酸整合的关系。抗病毒治疗的新概念。
J Hepatol. 1986;3 Suppl 2:S25-33. doi: 10.1016/s0168-8278(86)80097-6.
4
Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential.乙型肝炎病毒共价闭合环状 DNA:形成、调控和治疗潜力。
Antiviral Res. 2020 Aug;180:104824. doi: 10.1016/j.antiviral.2020.104824. Epub 2020 May 22.
5
Hepatitis B Virus Infection and Liver Decompensation.乙型肝炎病毒感染与肝功能失代偿
Clin Liver Dis. 2016 Nov;20(4):681-692. doi: 10.1016/j.cld.2016.07.002.
6
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H.3-羟基嘧啶-2,4-二酮作为靶向病毒核糖核酸酶H的新型乙型肝炎病毒抗病毒药物。
Antimicrob Agents Chemother. 2017 May 24;61(6). doi: 10.1128/AAC.00245-17. Print 2017 Jun.
7
Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.NVR 3-778 的临床前特征,一种针对乙型肝炎病毒的首创衣壳组装调节剂。
Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01734-18. Print 2019 Jan.
8
[HBV infection: antiviral therapy for viral replication].[乙肝病毒感染:针对病毒复制的抗病毒治疗]
Zhonghua Gan Zang Bing Za Zhi. 2023 Mar 20;31(3):316-318. doi: 10.3760/cma.j.cn501113-20220328-00147.
9
Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection.血红素加氧酶-1在乙型肝炎病毒感染中的抗病毒活性及肝脏保护作用
Gastroenterology. 2007 Oct;133(4):1156-65. doi: 10.1053/j.gastro.2007.07.021. Epub 2007 Jul 25.
10
Antiviral activities of Polygonum perfoliatum L. extract and related phenolic acid constituents against hepatitis B virus.贯叶连翘提取物及其相关酚酸成分抗乙型肝炎病毒的抗病毒活性。
J Med Virol. 2022 Dec;94(12):5987-5999. doi: 10.1002/jmv.28087. Epub 2022 Sep 1.

引用本文的文献

1
Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study.聚乙二醇干扰素α-2a联合小干扰RNA JNJ-73763989用于病毒学抑制的慢性乙型肝炎治疗:II期企鹅研究
JHEP Rep. 2025 Jul 9;7(10):101516. doi: 10.1016/j.jhepr.2025.101516. eCollection 2025 Oct.
2
HBV capsid assembly modulators differentially modulate the assembly of wild-type and drug-resistant core protein chimeric nucleocapsids and empty capsids.乙肝病毒衣壳组装调节剂对野生型和耐药核心蛋白嵌合核衣壳以及空衣壳的组装有不同的调节作用。
PLoS Pathog. 2025 Aug 5;21(8):e1013391. doi: 10.1371/journal.ppat.1013391. eCollection 2025 Aug.
3
Hepatitis B Virus Nucleocapsid Assembly.乙型肝炎病毒核衣壳组装
J Mol Biol. 2025 Apr 30:169182. doi: 10.1016/j.jmb.2025.169182.
4
Induction of hepatitis B core protein aggregation targeting an unconventional binding site.靶向非常规结合位点诱导乙肝核心蛋白聚集
Elife. 2025 Mar 26;13:RP98827. doi: 10.7554/eLife.98827.
5
PGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus.PGLYRP2通过捕获和清除乙型肝炎病毒来驱动肝细胞内在的先天免疫。
J Clin Invest. 2025 Feb 13;135(8). doi: 10.1172/JCI188083. eCollection 2025 Apr 15.
6
Opportunities and challenges for hepatitis B cure.治愈乙型肝炎的机遇与挑战。
eGastroenterology. 2023 Oct 25;1(2):e100021. doi: 10.1136/egastro-2023-100021. eCollection 2023 Sep.
7
Discovery of bimodal hepatitis B virus ribonuclease H and capsid assembly inhibitors.双峰型乙型肝炎病毒核糖核酸酶H和衣壳组装抑制剂的发现。
PLoS Pathog. 2025 Feb 10;21(2):e1012920. doi: 10.1371/journal.ppat.1012920. eCollection 2025 Feb.
8
Safety, pharmacokinetics, and antiviral efficacy of the novel capsid assembly modulator GST-HG141 in patients with chronic hepatitis B: a phase 1 trial with a randomized, placebo-controlled design.新型衣壳组装调节剂GST-HG141在慢性乙型肝炎患者中的安全性、药代动力学及抗病毒疗效:一项随机、安慰剂对照的1期试验
Virol J. 2024 Dec 20;21(1):328. doi: 10.1186/s12985-024-02584-8.
9
CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1.依赖CAM-A的乙肝病毒核心聚集通过膜联蛋白A1诱导细胞凋亡。
JHEP Rep. 2024 Jun 10;6(10):101134. doi: 10.1016/j.jhepr.2024.101134. eCollection 2024 Oct.
10
Small Molecule Assembly Agonist Alters the Dynamics of Hepatitis B Virus Core Protein Dimer and Capsid.小分子组装激动剂改变乙型肝炎病毒核心蛋白二聚体和衣壳的动力学。
J Am Chem Soc. 2024 Oct 23;146(42):28856-28865. doi: 10.1021/jacs.4c08871. Epub 2024 Oct 9.

本文引用的文献

1
Safety and efficacy of vebicorvir administered with entecavir in treatment-naïve patients with chronic hepatitis B virus infection.在初治慢性乙型肝炎病毒感染患者中,韦比科韦与恩替卡韦联合使用的安全性和有效性。
J Hepatol. 2022 Nov;77(5):1265-1275. doi: 10.1016/j.jhep.2022.05.027. Epub 2022 Jun 11.
2
Safety and efficacy of vebicorvir in virologically suppressed patients with chronic hepatitis B virus infection.韦柏ovir 在慢性乙型肝炎病毒感染病毒学抑制患者中的安全性和疗效。
J Hepatol. 2022 Sep;77(3):642-652. doi: 10.1016/j.jhep.2022.04.005. Epub 2022 Apr 20.
3
Current Progress in the Development of Hepatitis B Virus Capsid Assembly Modulators: Chemical Structure, Mode-of-Action and Efficacy.乙型肝炎病毒衣壳组装调节剂的研究进展:化学结构、作用模式和疗效。
Molecules. 2021 Dec 7;26(24):7420. doi: 10.3390/molecules26247420.
4
The Hepatitis B Virus Nucleocapsid-Dynamic Compartment for Infectious Virus Production and New Antiviral Target.乙肝病毒核衣壳——传染性病毒产生的动态区室及新的抗病毒靶点
Biomedicines. 2021 Oct 29;9(11):1577. doi: 10.3390/biomedicines9111577.
5
Novel Antivirals in Clinical Development for Chronic Hepatitis B Infection.用于慢性乙型肝炎感染的临床开发中的新型抗病毒药物。
Viruses. 2021 Jun 18;13(6):1169. doi: 10.3390/v13061169.
6
Identification of hepatitis B virus core protein residues critical for capsid assembly, pgRNA encapsidation and resistance to capsid assembly modulators.鉴定对衣壳组装、前基因组RNA(pgRNA)包装以及对衣壳组装调节剂抗性至关重要的乙型肝炎病毒核心蛋白残基。
Antiviral Res. 2021 Jul;191:105080. doi: 10.1016/j.antiviral.2021.105080. Epub 2021 Apr 30.
7
Local Stabilization of Subunit-Subunit Contacts Causes Global Destabilization of Hepatitis B Virus Capsids.亚基-亚基接触的局部稳定导致乙型肝炎病毒衣壳的整体不稳定。
ACS Chem Biol. 2020 Jun 19;15(6):1708-1717. doi: 10.1021/acschembio.0c00320. Epub 2020 May 19.
8
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379.JNJ-56136379 作为乙型肝炎病毒衣壳组装调节剂的抗病毒特性和作用机制研究。
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.02439-19.
9
The Structural Biology of Hepatitis B Virus: Form and Function.乙型肝炎病毒的结构生物学:形态与功能。
Annu Rev Virol. 2016 Sep 29;3(1):429-451. doi: 10.1146/annurev-virology-110615-042238. Epub 2016 Aug 1.

Nomenclature of HBV core protein-targeting antivirals.

作者信息

Zoulim Fabien, Zlotnick Adam, Buchholz Stephanie, Donaldson Eric, Fry John, Gaggar Anuj, Hu Jianming, Kann Michael, Lenz Oliver, Lin Kai, Mani Nagraj, Nassal Michael, Delaney William, Wang Su, Westman Gabriel, Miller Veronica, Janssen Harry L A

机构信息

Hepatology Department, INSERM Unit 1052, Hospices Civils de Lyon, Lyon University, Lyon, France.

Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, IN, USA.

出版信息

Nat Rev Gastroenterol Hepatol. 2022 Dec;19(12):748-750. doi: 10.1038/s41575-022-00700-z.

DOI:10.1038/s41575-022-00700-z
PMID:36207612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10442071/
Abstract
摘要