Sotgiu M L
Brain Res. 1987 Jun 30;414(2):219-27. doi: 10.1016/0006-8993(87)90002-3.
In urethane-anesthetized rabbits the effects of periaqueductal gray (PAG) and nucleus raphe magnus (NRM) stimulation on the spontaneous and noxious-evoked activity of the lateral reticular nucleus (LRN) neurons were studied. The PAG and the NRM stimulating electrodes were located in the optimal sites for suppressing the jaw-opening reflex (JOR) evoked by the tooth pulp stimulation. It was found that the 12% of neurons tested were affected by one or both stimuli. A total of 80 responsive neurons (52% antidromically activated by the cerebellum) were analyzed. Out of these neurons, 31 showed a convergence to both stimuli, 43 responded only to PAG and 6 only to NRM. Noxious heat stimulation of the contralateral foot was effective in altering the activity of 60% of these neurons. The PAG and NRM stimuli modified the noxious-evoked responses in most of these units. While the excitation was the predominant effect on the spontaneous activity (52 cells), the inhibition was predominant on the noxious-evoked activity (29 cells). These results indicate the presence of connections from PAG and NRM to LRN, probably devoted to the processing of the nociceptive information.
在氨基甲酸乙酯麻醉的家兔中，研究了中脑导水管周围灰质（PAG）和中缝大核（NRM）刺激对外侧网状核（LRN）神经元自发活动和伤害性刺激诱发活动的影响。PAG和NRM刺激电极位于抑制牙髓刺激诱发的张口反射（JOR）的最佳部位。结果发现，12%的受试神经元受到一种或两种刺激的影响。总共分析了80个反应性神经元（其中52%可被小脑逆向激活）。在这些神经元中，31个对两种刺激均有反应，43个仅对PAG有反应，6个仅对NRM有反应。对侧足部的伤害性热刺激可有效改变其中60%神经元的活动。PAG和NRM刺激改变了大多数这些神经元的伤害性刺激诱发反应。虽然兴奋是对自发活动的主要影响（52个细胞），但抑制是对伤害性刺激诱发活动的主要影响（29个细胞）。这些结果表明存在从PAG和NRM到LRN的连接，可能与伤害性信息的处理有关。
