Mason P, Strassman A, Maciewicz R
Brain Res. 1985 Mar 11;329(1-2):384-9. doi: 10.1016/0006-8993(85)90556-6.
The intracellular responses of pontomedullary raphe neurons to midbrain stimulation were studied in chloralose anesthetized cats. Electrical stimulation of the periaqueductal gray region at sites that suppressed the nociceptive jaw opening reflex evoked monosynaptic excitatory postsynaptic potentials in the majority of raphe neurons recorded. Intracellular labeling of studied cells demonstrated that recordings were obtained primarily from large and medium sized neurons in nucleus raphe magnus and the rostral nucleus raphe obscurus. These results provide further evidence that analgesia induced by periaqueductal gray stimulation may result in part from the direct activation of caudal raphe neurons.
在水合氯醛麻醉的猫中，研究了脑桥延髓中缝神经元对中脑刺激的细胞内反应。在抑制伤害性下颌张开反射的部位对导水管周围灰质区域进行电刺激，在大多数记录的中缝神经元中诱发了单突触兴奋性突触后电位。对研究细胞进行细胞内标记表明，记录主要来自中缝大核和中缝隐核嘴侧的大中型神经元。这些结果进一步证明，导水管周围灰质刺激诱导的镇痛作用可能部分源于尾侧中缝神经元的直接激活。
