Adjustment of the rat pineal N-acetyltransferase rhythm to eight-hour shifts of the light-dark cycle: advance of the cycle disturbs the rhythm more than delay.

After an 8-h delay of a light-dark (LD) cycle by lengthening of one light period, the rat pineal N-acetyltransferase (NAT) rhythm adjusted to the delay shift almost within one cycle. After an 8-h advance of the LD cycle by shortening of one dark period, the NAT rhythm adjusted to the advance shift within 5 cycles only; during the first 2-3 cycles the rhythm was abolished.