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衰老会改变大鼠在明暗周期改变后昼夜节律系统的重新同步化。

Aging alters resynchronization of the circadian system in rats after a shift of the light-dark cycle.

作者信息

Buresová M, Benesová O, Illnerová H

机构信息

Institute of Physiology, Czechoslovak Academy of Sciences, Prague.

出版信息

Experientia. 1990 Jan 15;46(1):75-7. doi: 10.1007/BF01955421.

DOI:10.1007/BF01955421
PMID:2298283
Abstract

Four days following an 8-h advance of the light-dark cycle, the circadian rhythms in the pineal N-acetyltransferase activity and melatonin content reappeared in 7-week-old rats, but were still abolished in 24-month-old animals.

摘要

在明暗周期提前8小时后的四天，7周龄大鼠松果体N-乙酰转移酶活性和褪黑素含量的昼夜节律重新出现，但在24月龄动物中仍被消除。

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2
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本文引用的文献

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Age-associated reduction in nocturnal pineal melatonin levels in female rats.雌性大鼠夜间松果体褪黑素水平随年龄增长而降低。
Endocrinology. 1981 Oct;109(4):1295-7. doi: 10.1210/endo-109-4-1295.
2
Free-running activity rhythms in the rat: entrainment by melatonin.大鼠的自由活动节律：褪黑素的同步作用。
Science. 1983 Mar 4;219(4588):1089-91. doi: 10.1126/science.6823571.
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Direct radioimmunoassay for melatonin in plasma.血浆中褪黑素的直接放射免疫测定法。
Clin Chem. 1983 Feb;29(2):396-7.
4
Age- and mental health-related circadian rhythms of plasma levels of melatonin, prolactin, luteinizing hormone and follicle-stimulating hormone in man.
J Endocrinol. 1981 Dec;91(3):467-75. doi: 10.1677/joe.0.0910467.
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Circadian rhythms and patterns of running-wheel activity, feeding and drinking behaviors of old male rats.老年雄性大鼠的昼夜节律以及跑轮活动、进食和饮水行为模式。
Physiol Behav. 1984 Oct;33(4):615-20. doi: 10.1016/0031-9384(84)90380-9.
6
Regulation of the pineal melatonin concentration in the rat (Rattus norvegicus) and in the Djungarian hamster (Phodopus sungorus).大鼠（褐家鼠）和黑线毛足鼠松果体褪黑素浓度的调节
Comp Biochem Physiol A Comp Physiol. 1983;74(1):155-9. doi: 10.1016/0300-9629(83)90727-2.
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Sensitive assay for serotonin N-acetyltransferase activity in rat pineal.大鼠松果体中血清素N-乙酰基转移酶活性的灵敏测定法。
Anal Biochem. 1972 Nov;50(1):174-9. doi: 10.1016/0003-2697(72)90496-4.
8
Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase.松果体中的吲哚代谢：N - 乙酰转移酶的昼夜节律。
Science. 1970 Sep 11;169(3950):1093-5. doi: 10.1126/science.169.3950.1093.
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Pineal homeostatic regulation of shifts in the circadian activity rhythm during maturation and aging.
Trans N Y Acad Sci. 1972 Mar;34(3):239-54. doi: 10.1111/j.2164-0947.1972.tb02679.x.
10
Circadian oscillations in rodents: a systematic increase of their frequency with age.啮齿动物的昼夜节律振荡：其频率随年龄增长而系统性增加。
Science. 1974 Nov 8;186(4163):548-50. doi: 10.1126/science.186.4163.548.