Sternberg H, Segall P E, Bellport V, Timiras P S
Brain Res. 1987 Aug;431(2):316-7. doi: 10.1016/0165-3806(87)90221-5.
We have assessed the activity (nmol/mg protein/h) of glutamic acid decarboxylase (GAD) in discrete hypothalamic nuclei before and after sexual maturation in the developing female rat. Activity in other brain regions including the cortex, septum and caudate-putamen was also assessed. While there appears to be a general rise (approximately 30%), with age, in GAD activity, the rise is most marked, and highly significant (P less than 0.001), in the anterior portion of the hypothalamus (56%). In contrast, no significant increase of GAD activity was found in the medical basal hypothalamus.
我们评估了发育中的雌性大鼠在性成熟前后，下丘脑各离散核团中谷氨酸脱羧酶（GAD）的活性（nmol/毫克蛋白质/小时）。还评估了包括皮质、隔区和尾状核 - 壳核在内的其他脑区的活性。虽然随着年龄增长，GAD活性似乎普遍上升（约30%），但在下丘脑前部，这种上升最为显著，且具有高度统计学意义（P小于0.001），上升幅度达56%。相比之下，在内侧基底下丘脑未发现GAD活性有显著增加。
