Hori T, Kiyohara T, Nakashima T, Shibata M, Koga H
Can J Physiol Pharmacol. 1987 Jun;65(6):1290-8. doi: 10.1139/y87-205.
The hypothesis that thermosensitive neurons in the preoptic anterior hypothalamic nuclei (POAH) have a principal role in central thermoregulation is based on numerous findings, suggesting correlations between the activity of thermosensitive neurons and thermoregulatory responses. Such relationships have been observed during thermal (local and peripheral) and pharmacological stimulation, during modulation of neural inputs from extra-POAH brain regions, and during actual thermoregulatory responses. Recent studies using in vitro slice preparations and conscious animals have revealed that 40-70% of POAH thermosensitive neurons respond to nonthermal homeostatic parameters such as local osmolality, blood pressure, and nonthermal emotional stimuli. About two-thirds of the POAH thermosensitive neurons, which responded in monkeys during bar press thermoregulatory tasks, changed their activity during bar press feeding behavior. A high degree of convergence of thermal and nonthermal homeostatic signals on the POAH neurons, together with abundant neural connections between the POAH and divergent areas of the brain, suggests that POAH thermosensitive neurons may be involved in the coordination of thermoregulation and nonthermal autonomic and behavioral responses controlled from the hypothalamus.
视前区下丘脑前核（POAH）中的热敏神经元在中枢体温调节中起主要作用这一假说，是基于众多研究结果得出的，这些结果表明热敏神经元的活动与体温调节反应之间存在相关性。在热刺激（局部和外周）、药理刺激、来自POAH以外脑区的神经输入调制以及实际体温调节反应过程中，均观察到了这种关系。最近使用体外脑片制备和清醒动物进行的研究表明，40% - 70%的POAH热敏神经元对非热稳态参数（如局部渗透压、血压和非热情绪刺激）有反应。在猴子进行压杆体温调节任务时做出反应的约三分之二的POAH热敏神经元，在压杆进食行为期间改变了它们的活动。热稳态信号和非热稳态信号在POAH神经元上的高度汇聚，以及POAH与大脑不同区域之间丰富的神经连接，表明POAH热敏神经元可能参与了由下丘脑控制的体温调节以及非热自主和行为反应的协调。
