Iishi H, Tatsuta M, Baba M, Okuda S, Taniguchi H
Cancer Res. 1987 Sep 15;47(18):4890-3.
The effects of vasoactive intestinal peptide (VIP) on the incidence and histology of colonic tumors induced by azoxymethane (AOM) were investigated in Wistar rats. Rats were given 20 micrograms/kg body weight of VIP every other day for 12 weeks and from experimental week 3, were given 10 weekly injections of 7.4 mg/kg body weight of AOM. The administration of VIP before and during AOM treatment resulted in a significant increase in the incidence of colonic tumors in week 40. Furthermore, it caused a significant increase in the labeling index of the colonic mucosa during AOM treatment. These findings indicate that VIP enhanced the development of colonic tumors. This effect may have been related to its effect in increasing proliferation of cells in the colonic mucosa during administration of the carcinogen.
研究了血管活性肠肽（VIP）对用偶氮甲烷（AOM）诱导的Wistar大鼠结肠肿瘤发生率和组织学的影响。大鼠每隔一天给予20微克/千克体重的VIP，持续12周，从实验第3周起，每周给予10次7.4毫克/千克体重的AOM注射。在AOM治疗前和治疗期间给予VIP导致第40周结肠肿瘤发生率显著增加。此外，它在AOM治疗期间导致结肠黏膜标记指数显著增加。这些发现表明VIP促进了结肠肿瘤的发展。这种作用可能与其在致癌物给药期间增加结肠黏膜细胞增殖的作用有关。
