Cherry Anne B C, Gherardin Nicholas A, Sikder Hafiz I
Axiom Healthcare Strategies, Princeton, NJ, United States.
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Front Oncol. 2022 Sep 23;12:1011081. doi: 10.3389/fonc.2022.1011081. eCollection 2022.
T cells play a key role in anticancer immunity, with responses mediated through a diversity of αβ or γδ T cell receptors. Although αβ and γδ T cells stem from common thymic precursors, the development and subsequent biological roles of these two subsets differ considerably. γδ T cells are an unconventional T cell subset, uniquely poised between the adaptive and innate immune systems, that possess the ability to recognize intracellular disturbances and non-peptide-based antigens to eliminate tumors. These distinctive features of γδ T cells have led to recent interest in developing γδ-inspired therapies for treating cancer patients. In this minireview, we explore the biology of γδ T cells, including how the γδ T cell immune surveillance system can detect intracellular disturbances, and propose a framework to understand the γδ T cell-inspired therapeutic strategies entering the clinic today.
T细胞在抗癌免疫中发挥关键作用，其反应通过多种αβ或γδT细胞受体介导。尽管αβ和γδT细胞起源于共同的胸腺前体，但这两个亚群的发育及后续生物学作用差异很大。γδT细胞是一类非常规T细胞亚群，独特地处于适应性免疫系统和固有免疫系统之间，具有识别细胞内紊乱和非肽类抗原以消除肿瘤的能力。γδT细胞的这些独特特征引发了近期对开发受γδT细胞启发的疗法来治疗癌症患者的兴趣。在本综述中，我们探讨了γδT细胞的生物学特性，包括γδT细胞免疫监视系统如何检测细胞内紊乱，并提出了一个框架来理解当今进入临床的受γδT细胞启发的治疗策略。
