Liu Yang, Tang Can, Wei Kailun, Liu Di, Tang Keke, Chen Meilian, Xia Xuewei, Mao Zhiqi
Department of Neurosurgery, Affiliated Hospital of Guilin Medical University, Guilin, China.
Guangzhou Kangzhi Digital Technology Co., Ltd., Guangzhou, China.
Front Neurol. 2022 Sep 23;13:962684. doi: 10.3389/fneur.2022.962684. eCollection 2022.
Transcranial alternating current stimulation (tACS) is a relatively new non-invasive brain electrical stimulation method for the treatment of patients with Alzheimer's disease (AD), but it has poor offline effects. Therefore, we applied a new combined stimulation method to observe the offline effect on the cognitive function of patients with AD. Here, we describe the clinical results of a case in which tACS combined with sound stimulation was applied to treat moderate AD. The patient was a 73-year-old woman with a 2-year history of persistent cognitive deterioration despite the administration of Aricept and Sodium Oligomannate. Therefore, the patient received tACS combined with sound stimulation. Her cognitive scale scores improved after 15 sessions and continued to improve at 4 months of follow-up. Although the current report may provide a new alternative therapy for patients with AD, more clinical data are needed to support its efficacy.
Clinicaltrials.gov, NCT05251649.
经颅交流电刺激（tACS）是一种相对较新的用于治疗阿尔茨海默病（AD）患者的非侵入性脑电刺激方法，但它的离线效果不佳。因此，我们应用了一种新的联合刺激方法来观察其对AD患者认知功能的离线影响。在此，我们描述了一例应用tACS联合声音刺激治疗中度AD的临床结果。该患者是一名73岁女性，尽管服用了多奈哌齐和寡聚甘露糖酸钠，但仍有2年持续认知功能恶化病史。因此，该患者接受了tACS联合声音刺激治疗。15次治疗后她的认知量表评分有所改善，并且在随访4个月时持续改善。尽管本报告可能为AD患者提供一种新的替代疗法，但仍需要更多临床数据来支持其疗效。
Clinicaltrials.gov，NCT05251649。
