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Determination of AAV properties by single amino acids: Go(o)d is in the details.

作者信息

Maiakovska Olena, Baumgartl Conradin, Grimm Dirk

机构信息

Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, Center for Integrative Infectious Diseases Research (CIID), BioQuant, 69120 Heidelberg, Germany.

German Center for Infection Research (DZIF), Partner Site Heidelberg, 69120 Heidelberg, Germany.

出版信息

Mol Ther Methods Clin Dev. 2022 Sep 29;27:93-95. doi: 10.1016/j.omtm.2022.09.006. eCollection 2022 Dec 8.

DOI:10.1016/j.omtm.2022.09.006
PMID:36212908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9529493/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67af/9529493/1f0194cca2ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67af/9529493/1f0194cca2ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67af/9529493/1f0194cca2ef/gr1.jpg

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Deep diversification of an AAV capsid protein by machine learning.机器学习深度多样化 AAV 衣壳蛋白。
Nat Biotechnol. 2021 Jun;39(6):691-696. doi: 10.1038/s41587-020-00793-4. Epub 2021 Feb 11.
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Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity.
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J Virol. 2020 May 18;94(11). doi: 10.1128/JVI.00170-20.
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Nat Commun. 2014;5:3075. doi: 10.1038/ncomms4075.
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Gene Ther. 2009 Dec;16(12):1416-28. doi: 10.1038/gt.2009.101.
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