握力对中国老年人膳食蛋白质摄入量与认知功能关联的甘油三酯水平及亚甲基四氢叶酸还原酶特异性中介效应

Triglyceride Level- and MTHFR-Specific Mediation Effect of Handgrip Strength on the Association of Dietary Protein Intake and Cognitive Function in the Chinese Elderly.

作者信息

Huang Ling, Liu Qian, Fu Jingzhu, Zhou Dezheng, Sun Yue, Duan Huilian, Yang Tong, Zhao Jing, Wang Zehao, Li Zhenshu, Dong Cuixia, Xu Ning, Ren Qinghan, Zhang Guoquan, Li Wen, Ma Fei, Yan Jing, Du Yue, Liu Huan, Sun Changqing, Wang Guangshun, Huang Guowei, Chen Yongjie

机构信息

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.

Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.

出版信息

Curr Alzheimer Res. 2022;19(9):658-666. doi: 10.2174/1567205019666221007093500.

DOI:10.2174/1567205019666221007093500

PMID:36214304

Abstract

BACKGROUND

Recent findings suggest that both dietary protein intake and hand grip strength (HGS) were associated with cognitive function, however, few studies have been devoted specifically to the mediation effect of HGS on the association of the dietary protein with cognitive function.

OBJECTIVE

To confirm the hypothesis that HGS mediated the association of dietary protein intake with cognitive function in the elderly, which was modified by triglyceride level and methylenetetrahydrofolate reductase (MTHFR) gene status.

METHODS

This cross-sectional study included 3,268 participants. Dietary protein intake, HGS, and cognitive function were collected by food frequency questionnaires (FFQ), grip measurements and mini mental state examination (MMSE), respectively. In this mediation analysis, dietary protein intake was entered as an independent variable, HGS was entered as a mediator, and cognitive function was entered as a dependent variable.

RESULTS

HGS significantly mediated the associations of dietary protein (β = 0.0013, 95% CI: 0.0007, 0.0022), animal protein (β = 0.0024, 95% CI: 0.0012, 0.0037), and plant protein intake (β = 0.0011, 95% CI: 0.0001, 0.0023) with cognitive function in total participants, with the mediated proportion of 16.19%, 12.45% and 20.57%, respectively. Furthermore, significant mediation effects of HGS on the associations of dietary protein, animal protein, and plant protein intake with MMSE score were found in the elderly without hypertriglyceridemia or in MTHFR C677T CC/CT carriers.

CONCLUSION

This study suggested that HGS mediated the association of dietary protein intake with cognitive function, and this mediation effect was modified by triglyceride level and MTHFR C677T gene status.

摘要

背景

最近的研究结果表明，膳食蛋白质摄入量和握力（HGS）均与认知功能相关，然而，很少有研究专门探讨HGS在膳食蛋白质与认知功能关联中的中介作用。

目的

验证HGS介导老年人膳食蛋白质摄入量与认知功能之间的关联这一假设，该关联受甘油三酯水平和亚甲基四氢叶酸还原酶（MTHFR）基因状态的影响。

方法

这项横断面研究纳入了3268名参与者。膳食蛋白质摄入量、HGS和认知功能分别通过食物频率问卷（FFQ）、握力测量和简易精神状态检查（MMSE）进行收集。在这项中介分析中，将膳食蛋白质摄入量作为自变量，HGS作为中介变量，认知功能作为因变量。

结果

在所有参与者中，HGS显著介导了膳食蛋白质（β = 0.0013，95%CI：0.0007，0.0022）、动物蛋白（β = 0.0024，95%CI：0.0012，0.0037）和植物蛋白摄入量（β = 0.0011，95%CI：0.0001，0.0023）与认知功能之间的关联，中介比例分别为16.19%、12.45%和20.57%。此外，在无高甘油三酯血症的老年人或MTHFR C677T CC/CT携带者中，发现HGS对膳食蛋白质、动物蛋白和植物蛋白摄入量与MMSE评分之间的关联有显著中介作用。