Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.
J Alzheimers Dis. 2021;80(4):1503-1513. doi: 10.3233/JAD-201537.
Handgrip strength (HGS) and serum folate and homocysteine (Hcy) levels were associated with cognitive function. However, little was known whether there were interactions between HGS and serum folate and Hcy levels on cognitive function.
To examine the interactions between HGS and serum folate and Hcy levels on cognitive function.
This study analyzed the baseline data of the Tianjin Elderly Nutrition and Cognition Cohort study. All participants aged ≥60 years were potential eligible. HGS was measured using a grip strength dynamometer. Serum folate and Hcy levels were assayed using standard laboratory protocol. A Mini-Mental State Examination was used to assess cognitive function. Linear regressions were employed to examine the interactions between HGS and serum folate and Hcy levels on cognitive function.
4,484 participants were included in this study. There were interactions between HGS and serum folate and Hcy levels on cognitive function. Furthermore, subjects with strong HGS and sufficient folate level had the best cognitive function (β= 2.018), sequentially followed by those with strong HGS and insufficient folate level (β= 1.698) and with poor HGS and sufficient folate level (β= 0.873). Similarly, cognitive function was ranked in the descending order of subjects with strong HGS and normal Hcy level (β= 1.971), strong HGS and high Hcy level (β= 1.467), and poor HGS and normal Hcy level (β= 0.657).
There were interactions between HGS and serum folate and Hcy levels on cognitive function. However, the temporal associations cannot be examined in a cross-sectional study. Further cohort study should be conducted to confirm these associations in the future.
握力（HGS）和血清叶酸及同型半胱氨酸（Hcy）水平与认知功能有关。然而，对于 HGS 与血清叶酸和 Hcy 水平之间是否存在对认知功能的相互作用知之甚少。
研究 HGS 与血清叶酸和 Hcy 水平对认知功能的相互作用。
本研究分析了天津老年营养与认知队列研究的基线数据。所有年龄≥60 岁的参与者均为潜在合格者。使用握力测力计测量 HGS。使用标准实验室方案测定血清叶酸和 Hcy 水平。采用简易精神状态检查量表评估认知功能。线性回归用于检验 HGS 与血清叶酸和 Hcy 水平对认知功能的相互作用。
本研究共纳入 4484 名参与者。HGS 与血清叶酸和 Hcy 水平对认知功能存在交互作用。此外，握力强且叶酸水平充足的受试者认知功能最佳（β=2.018），其次是握力强但叶酸水平不足的受试者（β=1.698）和握力差但叶酸水平充足的受试者（β=0.873）。同样，认知功能的顺序依次为握力强且 Hcy 水平正常的受试者（β=1.971）、握力强且 Hcy 水平高的受试者（β=1.467）和握力差且 Hcy 水平正常的受试者（β=0.657）。
HGS 与血清叶酸和 Hcy 水平对认知功能存在相互作用。然而，在横断面研究中无法检测到时间关联。未来应进行进一步的队列研究来证实这些关联。
