Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, People's Republic of China.
Department of Nursing and Health Management, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Clin Interv Aging. 2021 Jan 12;16:119-127. doi: 10.2147/CIA.S288164. eCollection 2021.
This study aimed to examine the relationship between physical performance and mild cognitive impairment (MCI) in Chinese older adults.
The sample comprised 956 relatively healthy and aged ≥65 years old Chinese community-dwelling participants (mean age, 72.56 ± 5.43 years; 56.8% female), which did not include those with dementia, severe cognitive impairment, mental illness etc. The Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale were used for the initial classification of patients with MCI. Physical performance was measured via hand grip, Timed Up and Go Test (TUGT), and 4-m walking speed.
The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. The grip strength [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.93-0.99] and 4-m walking speed (OR = 0.25, 95% CI = 0.10-0.64) correlated negatively with MCI, while TUGT (OR = 1.08, 95% CI = 1.03-1.13) and MCI correlated positively.
The physical performance (grip strength, TUGT, and 4-m walking speed) correlated with MCI. Further analysis showed that the grip strength was associated with overall cognition, time orientation, recall, and language, while TUGT and 4-m walking speed were associated with overall cognition and various cognitive domains, except recall.
本研究旨在探讨中国老年人身体机能与轻度认知障碍（MCI）之间的关系。
本研究共纳入 956 名年龄≥65 岁且相对健康的中国社区居住者（平均年龄 72.56±5.43 岁，56.8%为女性），不包括痴呆症、严重认知障碍、精神疾病等患者。采用简易精神状态检查量表（MMSE）和工具性日常生活活动量表（IADL）对 MCI 患者进行初步分类。采用握力、计时起立行走测试（TUGT）和 4 米步行速度评估身体机能。
身体机能（握力、TUGT、4 米步行速度）与 MCI 相关。握力[比值比（OR）=0.96，95%置信区间（CI）=0.93-0.99]和 4 米步行速度（OR=0.25，95%CI=0.10-0.64）与 MCI 呈负相关，而 TUGT（OR=1.08，95%CI=1.03-1.13）与 MCI 呈正相关。
身体机能（握力、TUGT、4 米步行速度）与 MCI 相关。进一步分析显示，握力与整体认知、时间定向、回忆和语言相关，而 TUGT 和 4 米步行速度与整体认知和多种认知领域相关，除了回忆。
