成人异基因造血干细胞移植患者应用静脉注射喷他脒预防卡氏肺孢子菌肺炎。
Pneumocystis jirovecii Pneumonia Prophylaxis with Intravenous Pentamidine in Adult Allogeneic Hematopoietic Stem Cell Transplant Patients.
机构信息
Oregon Health and Science University Hospitals and Clinics, Portland, Oregon, USA.
出版信息
Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0083322. doi: 10.1128/aac.00833-22. Epub 2022 Oct 10.
Abstract
The purpose of this single-center retrospective case series was to evaluate the efficacy and safety of 300-mg once-monthly intravenous (IV) pentamidine prophylaxis in 702 adult allogeneic hematopoietic stem cell transplant (HSCT) patients. We observed no cases of Pneumocystis jirovecii pneumonia (PJP) following IV pentamidine administration. Breakthrough and infections were observed in 7 (1%) and 5 (0.7%) patients, respectively. The most commonly reported adverse event was nausea. Monthly IV pentamidine is a reasonable alternative to trimethoprim-sulfamethoxazole (TMP-SMX).
摘要
本单中心回顾性病例系列研究的目的是评估 702 例异基因造血干细胞移植（HSCT）成人患者中 300mg 每月一次静脉注射（IV）戊烷脒预防的疗效和安全性。我们在 IV 戊烷脒给药后没有观察到耶氏肺孢子菌肺炎（PJP）的病例。分别有 7 例（1%）和 5 例（0.7%）患者出现突破性感染和感染。最常见的不良事件是恶心。每月一次 IV 戊烷脒是替代甲氧苄啶-磺胺甲恶唑（TMP-SMX）的合理选择。
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本文引用的文献
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ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients.欧洲癌症研究与治疗组织血液病/造血干细胞移植患者肺孢子菌肺炎预防指南。
J Antimicrob Chemother. 2016 Sep;71(9):2397-404. doi: 10.1093/jac/dkw157. Epub 2016 May 12.
2
Prevention and Treatment of Cancer-Related Infections, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology.《癌症相关感染的预防和治疗》，第 2.2016 版，NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2016 Jul;14(7):882-913. doi: 10.6004/jnccn.2016.0093.
3
The incidence, mortality and timing of Pneumocystis jiroveci pneumonia after hematopoietic cell transplantation: a CIBMTR analysis.造血细胞移植后耶氏肺孢子菌肺炎的发病率、死亡率及发病时间：一项国际骨髓移植登记处（CIBMTR）分析
Bone Marrow Transplant. 2016 Apr;51(4):573-80. doi: 10.1038/bmt.2015.316. Epub 2016 Jan 4.
4
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5
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