Department of Pharmaceutical Technology, Faculty of Pharmacy, İzmir Kâtip Çelebi University, İzmir, Turkey.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
J Pharm Pharmacol. 2022 Oct 10;74(10):1406-1426. doi: 10.1093/jpp/rgab139.
Three-dimensional printing (3DP) has gained importance worldwide recently as a novel drug manufacturing technology. 3DP technologies are suitable in the pharmaceutical field because of having the potential in personalized medicine. The aim of this review is to present an overview of the use of 3DP technologies in pharmaceutical area, their working principles and critical process parameters. In addition, this review presents an innovative approach that evaluates the use of 3DP technologies on disease to disease.
This review covers the potential use of 3DP technologies in different diseases by evaluating them on a research basis. These diseases can be summarized as cardiovascular, neurological, respiratory, oncological, inflammatory, vaginal, dermatological and other diseases. It has been focussed on manuscripts that published after 2015. Studies on the use of 3DP in each disease group have been systematically reviewed by considering the methods, types of printers used and the prepared dosage forms. Oral formulations (tablets and films), implants, topical systems and vaccines are some of the examples of the mentioned dosage forms.
This review presented a systematic and novel overview of the use of 3DP in the treatment of different clinical disorders.
三维打印（3DP）作为一种新颖的药物制造技术，最近在全球范围内得到了重视。3DP 技术在制药领域具有适用性，因为其具有个性化医疗的潜力。本综述的目的是概述 3DP 技术在制药领域的应用，及其工作原理和关键工艺参数。此外，本综述还提出了一种创新方法，即评估 3DP 技术在疾病治疗中的应用。
本综述通过基于研究的评估，涵盖了 3DP 技术在不同疾病中的潜在应用。这些疾病可以概括为心血管疾病、神经疾病、呼吸疾病、肿瘤疾病、炎症疾病、阴道疾病、皮肤病和其他疾病。综述重点关注了 2015 年后发表的文献。通过考虑所使用的方法、打印机类型和制备的剂型，对每个疾病组中使用 3DP 的研究进行了系统的综述。口腔制剂（片剂和薄膜）、植入物、局部系统和疫苗是提到的剂型的一些示例。
本综述对 3DP 在治疗不同临床疾病中的应用进行了系统的、新颖的概述。
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