西咪替丁治疗急性间歇性卟啉症的临床效用——初步报告
Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report.
作者信息
Horie Y, Udagawa M, Hirayama C
出版信息
Clin Chim Acta. 1987 Aug 31;167(3):267-71. doi: 10.1016/0009-8981(87)90346-9.
PMID:3621613
Abstract
A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria. Urinary prophobilinogen and porphyrins were not altered by the treatment, but urinary delta-aminolevulinic acid decreased, and abdominal fullness disappeared. Thus, cimetidine may control acute intermittent porphyria by inhibiting hepatic delta-aminolevulinic acid synthetase.
摘要
一名43岁腹部胀满的男性在急性间歇性卟啉症缓解期接受西咪替丁口服治疗。治疗后尿中胆色素原和卟啉未发生改变，但尿中δ-氨基-γ-酮戊酸减少，腹部胀满消失。因此，西咪替丁可能通过抑制肝脏δ-氨基-γ-酮戊酸合成酶来控制急性间歇性卟啉症。
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