McColl K E, Thompson G T, Moore M R, Goldberg A
Lancet. 1979 Jan 20;1(8108):133-4. doi: 10.1016/s0140-6736(79)90522-1.
The activity of leucocyte delta-aminolaevulinic-acid (A.L.A.) synthase was monitored throughout a prolonged attack of acute intermittent porphyria in a 29-year-old women. Clinical severity was associated with a pronounced increase in activity of this enzyme and high urinary excretion of A.L.A. Haematin therapy resulted in clinical improvement associated with a reduction in the activity of A.L.A. synthase and reduction in urinary excretion of A.L.A.
