Foresta C, Mioni R, Scandellari C
Clin Endocrinol (Oxf). 1986 Nov;25(5):573-8. doi: 10.1111/j.1365-2265.1986.tb03611.x.
Endogenous opioid peptides tonically inhibit LH by acting on hypothalamic mechanisms which regulate LHRH secretion. Opiates increase hypothalamic serotonin turnover but the involvement of the serotoninergic system in the opioid mechanisms regulating LH secretion in man is not clear at present. This study was designed to evaluate whether the tonic inhibitory effect on LH secretion induced by opiates involves the serotoninergic system. We have studied 10 healthy young men (aged 20-28 years). Five subjects were infused with naloxone (10 mg/h for 3 h) before and 120 min after fenfluramine administration (60 mg orally) on two different occasions. In five other subjects naloxone was infused before and after metergoline pretreatment (8 mg on first and second day and 4 mg on the third day, orally, at 0 time of naloxone infusion). After fenfluramine, naloxone infusion failed to induce any increase in LH plasma levels; metergoline pretreatment significantly enhanced the naloxone-induced LH increase. These data suggest that in man a hypothalamic serotoninergic system may be involved in the opioid mechanisms regulating LH secretion.
内源性阿片肽通过作用于调节促性腺激素释放激素（LHRH）分泌的下丘脑机制，对促黄体生成素（LH）产生持续性抑制作用。阿片类药物可增加下丘脑5-羟色胺（血清素）的转换率，但目前尚不清楚5-羟色胺能系统是否参与阿片类药物调节人类LH分泌的机制。本研究旨在评估阿片类药物对LH分泌的持续性抑制作用是否涉及5-羟色胺能系统。我们研究了10名健康青年男性（年龄20 - 28岁）。在两个不同的时间段，5名受试者在口服芬氟拉明（60mg）前及服药后120分钟，静脉输注纳洛酮（10mg/h，共3小时）。另外5名受试者在静脉输注纳洛酮前及甲氧氯普胺预处理后（第一天和第二天口服8mg，第三天口服4mg，在输注纳洛酮的0时服用），静脉输注纳洛酮。芬氟拉明给药后，输注纳洛酮未能使LH血浆水平升高；甲氧氯普胺预处理显著增强了纳洛酮诱导的LH升高。这些数据表明，在人类中，下丘脑5-羟色胺能系统可能参与了阿片类药物调节LH分泌的机制。
