Department of Operative Dentistry, Endodontics and Dental Materials, São Paulo University - USP, Bauru School of Dentistry, Dr. Octavio Pinheiro Brizola, 9-75, Bauru, Sao Paulo 17012-901, Brazil.
Faculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Level 10, Singapore 119085, Singapore.
Dent Clin North Am. 2022 Oct;66(4):643-657. doi: 10.1016/j.cden.2022.05.010. Epub 2022 Sep 11.
Novel technologies and platforms have allowed significant breakthroughs in dental pulp tissue engineering. The development of injectable scaffolds that can be combined with stem cells, growth factors, or other bioactive compounds has enabled the regeneration of functional dental pulps able to secrete dentin in preclinical and clinical studies. Similarly, cell-homing technologies and scaffold-free strategies aim to modulate dental pulp self-regeneration mediated by resident stem cells and can evade some of the technical challenges related to cell-based tissue engineering strategies. This article will discuss emerging technologies and platforms for the clinical applications of dental pulp tissue engineering.
新型技术和平台使得牙髓组织工程学取得了重大突破。可注射支架的发展可以与干细胞、生长因子或其他生物活性化合物结合，使得能够在临床前和临床研究中再生具有分泌牙本质功能的功能性牙髓。同样，细胞归巢技术和无支架策略旨在调节由驻留干细胞介导的牙髓自我再生，并可以规避与基于细胞的组织工程策略相关的一些技术挑战。本文将讨论牙髓组织工程临床应用的新兴技术和平台。
