Galler Kerstin M, Eidt Andreas, Schmalz Gottfried
Department of Restorative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany.
Department of Restorative Dentistry and Periodontology, University of Regensburg, Regensburg, Germany.
J Endod. 2014 Apr;40(4 Suppl):S41-5. doi: 10.1016/j.joen.2014.01.014.
The standard treatment modality for teeth with irreversibly damaged dental pulp is root canal therapy, which involves complete removal of the soft tissue and obturation with a synthetic material. So far, research studies show that the combination of stem cells with a suitable scaffold material and transplantation into the root canal may result in the generation of pulplike tissue and the formation of tubular dentin. Because of the technical challenges associated with such a procedure, cell-free alternatives that take advantage of the dental pulp's inherent regenerative capacity because of endogenous stem cell populations and bioactive dentin matrix components need to be considered and explored. Following the tissue engineering approach, this includes (1) a bioactive scaffold, (2) growth and differentiation factors from dentin, and (3) the recruitment of stem cells from resident populations within the pulp or from the periapical region. If this concept proved to be successful, cell-free therapies may be a safer, more practical, feasible, and affordable approach to dental pulp regeneration.
对于牙髓发生不可逆损伤的牙齿，标准治疗方式是根管治疗，即彻底清除软组织并用合成材料进行充填。到目前为止，研究表明，将干细胞与合适的支架材料相结合并移植到根管中，可能会产生牙髓样组织并形成管状牙本质。由于这种操作存在技术挑战，因此需要考虑和探索利用牙髓内源性干细胞群体和生物活性牙本质基质成分所具有的固有再生能力的无细胞替代方案。按照组织工程方法，这包括：（1）生物活性支架；（2）来自牙本质的生长和分化因子；（3）从牙髓内或根尖周区域的常驻细胞群体中募集干细胞。如果这一概念被证明是成功的，无细胞疗法可能是一种更安全、更实用、可行且经济的牙髓再生方法。
