Biosynthesis of phyto functionalized cerium oxide nanoparticles mediated from Scoparia dulsis L. for appraisal of anti-cancer potential against adenocarcinomic lung cancer cells and paracetamol sensing potentiality.

This research work aims at the eco-friendly preparation of cerium oxide nanoparticles (CeSD NPs) utilizing the natural extract of Scoparia dulsis L. An attempt was made to analyze the influence of the fuel load on the size, shape, and optical properties of the nanoparticles. The p-XRD studies revealed the controlled formation of NPs with a size not more than 12.74 nm. The surface area studies appraise the mesoporous nature of the synthesized ceria particles, with the maximum specific surface area of 36.06 mg. The nano-regime CeO nanoparticles had a definite impact on biomedical and electrochemical studies. The CeSD NPs with minuscule size (10.69 nm) manifested promising antioxidant and human RBC protection activity. The antioxidant properties were evaluated using % DPPH inhibition with of maximum of 83.38. The stabilization of RBC's by CeSD NPs was maximum at 94.97%. However, the CeSD NPs with apparent size (12.74 nm) that utilized greater volume fuel (25 mL) had noticeable results on adenocarcinomic lung (A549) cancer cell viability and antidiabetic study which was maximum of 70.16% at concentration 500 μg/mL. A satisfactory antibacterial application was proffered against chosen bacterial stains. The smallest size CeO NPs exhibited the best proton diffusion coefficient (8.16 × 10 cms), and the capacitance values of the CeSD NPs are near in all samples (~ 1.17 to 2.00 F) manifest their compact nano-regime sizes. The paracetamol drug was chosen as analyte to appreciating the superlative efficiency for sensing paracetamol drug with the lowest detection limit.