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DCAF-13是生长、发育和生育所必需的。

DCAF-13 is required for growth, development, and fertility.

作者信息

Durkan Aidan, Byrnes Catherine, Cooper Emily, Hally Alyson, Sullivan-Brown Jessica, Sowa Jessica

机构信息

West Chester University of Pennsylvania.

出版信息

MicroPubl Biol. 2022 Sep 23;2022. doi: 10.17912/micropub.biology.000641. eCollection 2022.

DOI:10.17912/micropub.biology.000641
PMID:36217444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9547275/
Abstract

DCAF13 (DDB1 and CUL4 associated factor 13) is a potential oncogene but little is understood about the developmental roles of this highly conserved gene. We characterized the RNAi phenotypes of , the homolog of DCAF13, and show that compared to age-matched control worms, body length is decreased in (RNAi) larvae, suggesting a role of in larval development. In addition, (RNAi) worms display either a failure or delay in reaching the L4 and adult stages. Our data also indicates that (RNAi) treatment beginning at L4 stage does not increase embryonic lethality in progeny; however, progeny production was significantly decreased in (RNAi) worms, suggesting a general role in fertility and perhaps oocyte development.

摘要

DCAF13（DDB1和CUL4相关因子13）是一种潜在的致癌基因，但对于这个高度保守基因的发育作用了解甚少。我们对DCAF13的同源物——[具体名称未给出]的RNA干扰表型进行了表征，并表明与年龄匹配的对照蠕虫相比，[具体名称未给出]（RNA干扰）幼虫的体长缩短，这表明[具体名称未给出]在幼虫发育中发挥作用。此外，[具体名称未给出]（RNA干扰）蠕虫在达到L4期和成虫期时出现失败或延迟。我们的数据还表明，从L4期开始进行[具体名称未给出]（RNA干扰）处理不会增加后代的胚胎致死率；然而，[具体名称未给出]（RNA干扰）蠕虫的后代产量显著降低，这表明[具体名称未给出]在生育能力以及可能在卵母细胞发育中具有普遍作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ec/9547275/607c118849e7/25789430-2022-micropub.biology.000641.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ec/9547275/607c118849e7/25789430-2022-micropub.biology.000641.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7ec/9547275/607c118849e7/25789430-2022-micropub.biology.000641.jpg

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