Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, P. R. China.
Org Biomol Chem. 2022 Oct 26;20(41):8120-8124. doi: 10.1039/d2ob01493a.
A Pd-catalyzed annulation between 1-(2-iodophenyl)-1-indoles and sodium difluorochloroacetate has been developed to synthesize 10-indolo[1,2-]indol-10-one derivatives C-H bond activation and difluorocarbene transfer. Our route enables facile access to the targeted products with various substituents in moderate to high yields. This method features high reactivity, good functional group tolerance, a simple operation procedure, and mild reaction conditions. The reaction can be carried out on a gram scale.
Pd 催化的 1-(2-碘苯基)-1-吲哚与二氟氯乙酸钠的环化反应已经被开发出来，用于合成 10-吲哚[1,2-a]吲哚-10-酮衍生物的 C-H 键活化和二氟碳烯转移。我们的路线能够以中等到高产率简便地获得具有各种取代基的目标产物。该方法具有高反应性、良好的官能团耐受性、简单的操作程序和温和的反应条件。反应可以在克级规模上进行。
