Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
Bahria International Hospital, Lahore, Pakistan.
Pak J Pharm Sci. 2022 Jul;35(4(Special)):1209-1213.
Traditional medicine has employed the plant Fagonia bruguieri DC. to alleviate inflammation, fever and pain. The goal of this study was to test the anti-inflammatory, analgesic and antipyretic properties of the methanol extract of whole plant of Fagonia bruguieri (F. bruguieri). The writhing test and Eddy's hot plate test were used to assess the analgesic potential of F. bruguieri at three different doses. Carrageenan-induced rat paw edema was applied to investigate anti-inflammatory activity, whereas antipyretic activity was estimated in Brewer's yeast induced pyrexia model. Flavonoids, alkaloids, saponins, tannins and glycosides were found in F. bruguieri's phytochemical analysis. F. bruguieri at 750 mg/kg reduced writhing count by 62.23 percent, while F. bruguieri enhanced latency in Eddy's hot plate test. In carrageenan-induced edema, F. bruguieri at 750 mg/kg exhibited considerable anti-inflammatory effect (41.11 percent) after 2 , 3 and 4 hours of therapy. F. bruguieri was also found to show antipyretic properties. The anti-inflammatory, analgesic and antipyretic properties of F. bruguieri were confirmed in this study, which might be attributable to the presence of several phyto-constituents.
传统医学使用 Bruguiera gymnorrhiza 植物来缓解炎症、发热和疼痛。本研究的目的是测试全草甲醇提取物的抗炎、镇痛和退热特性。扭体试验和 Eddy 热板试验用于评估 F. bruguieri 在三个不同剂量下的镇痛潜力。角叉菜胶诱导的大鼠足肿胀用于研究抗炎活性，而在 Brewer 酵母诱导的发热模型中评估退热活性。在 F. bruguieri 的植物化学分析中发现了类黄酮、生物碱、皂苷、单宁和糖苷。750mg/kg 的 F. bruguieri 减少扭体次数 62.23%，同时 F. bruguieri 提高 Eddy 热板试验的潜伏期。在角叉菜胶诱导的水肿中，750mg/kg 的 F. bruguieri 在治疗后 2、3 和 4 小时表现出显著的抗炎作用（41.11%）。F. bruguieri 还显示出退热特性。本研究证实了 F. bruguieri 的抗炎、镇痛和退热特性，这可能归因于几种植物成分的存在。
