灰岩鳞花草（爵床科）的抗炎、镇痛和解热作用。
Anti-inflammatory, analgesic and antipyretic effects of Lepidagathis anobrya Nees (Acanthaceae).
作者信息
Richard Sawadogo Wamtinga, Marius Lompo, Noya Somé, Innocent Pierre Guissou, Germaine Nacoulma-Ouedraogo Odile
机构信息
Institut de recherche en sciences de la santé 03 BP 7192 Ouagadougou 01/ Burkina Faso.
出版信息
Afr J Tradit Complement Altern Med. 2011;8(4):420-4. doi: 10.4314/ajtcam.v8i4.12. Epub 2011 Jun 1.
This study investigated the general acute, anti-inflammatory, analgesic and antipyretic effects of methanol extract of Lepidagathis anobrya Nees (Acanthaceae). Carrageenan-induced rat paw edema and croton oil-induced ear edema in rats were used for the evaluation of general acute anti-inflammatory effects. Acetic acid-induced writhing response and yeast-induced hyperpyrexia in mice were used to evaluate the analgesic and antipyretic activities respectively. The extract at doses of 10, 25, 50 and 100 mgkg(-1) for carrageenan test and doses of 0.5 mg/ear for croton oil test induced a significant reduction (p < 0.001) of paw and ear edemas in rats. In the analgesic and antipyretic tests, the extract has shown a significant inhibition of writhes and hyperpyrexia with all the doses used when compared to the untreated control group. These results clearly show the anti-inflammatory, analgesic and antipyretic effects of the methanol extract of Lepidagathis anobrya and give the scientific basis for its traditional use. Further studies are needed to clarify the mechanism of action and the components responsible for these pharmacological effects.
本研究考察了鳞花草属植物（爵床科）甲醇提取物的一般急性、抗炎、镇痛和解热作用。采用角叉菜胶诱导的大鼠足爪肿胀和巴豆油诱导的大鼠耳肿胀来评价其一般急性抗炎作用。分别采用乙酸诱导的小鼠扭体反应和酵母诱导的小鼠高热来评价其镇痛和解热活性。在角叉菜胶试验中，提取物剂量为10、25、50和100 mg/kg(-1)，在巴豆油试验中剂量为0.5 mg/耳，均能显著减轻（p < 0.001）大鼠的足爪和耳肿胀。在镇痛和解热试验中，与未处理的对照组相比，提取物在所有使用剂量下均能显著抑制扭体反应和高热。这些结果清楚地表明了鳞花草甲醇提取物的抗炎、镇痛和解热作用，并为其传统用途提供了科学依据。需要进一步研究以阐明其作用机制以及产生这些药理作用的成分。
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