Department of Nuclear Medicine, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India.
Department of Urology, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India.
Diagn Interv Radiol. 2022 Sep;28(5):498-502. doi: 10.5152/dir.2022.21096.
PURPOSE The aim of this study was to compare 18F-fluorodeoxyglucose positron emission tomography- computed tomography (18F-FDG PET/CT) scan with computed tomography (CT) scan for detecting recurrence and metastasis in renal cell carcinoma patients. METHODS This retrospective study included patients from October 2013 to April 2017. Contrast-enhanced CT and PET/CT scans were compared and correlated with histopathology or/and follow-up studies. RESULTS Seventy-six patients, 60 males, were included. Lesions included primary renal, recurrent renal fossa lesions, lymph nodes, and distant metastatic lesions. Of 176 malignant lesions, CT detected 157 lesions; of which, 154 were true positive. Twenty-two false-negative lesions showed abnormal FDG uptake. CT scan had positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity, and accuracy of 98.0%, 37.1%, 87.5%, 81.2%, and 86.9%, respectively. All 176 lesions were PET/CT-positive. PET/CT had PPV, NPV, sensitivity, specificity, and accuracy of 100% each. The specificity and NPV of PET/CT were superior (P < .05). CONCLUSION PET/CT appears more accurate than CT scan for detecting metastasis and recurrence in renal cell carcinoma patients.
本研究旨在比较 18F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（18F-FDG PET/CT）与计算机断层扫描（CT）在检测肾细胞癌患者复发和转移中的作用。
这是一项回顾性研究，纳入了 2013 年 10 月至 2017 年 4 月期间的患者。将增强 CT 和 PET/CT 扫描结果进行对比，并与组织病理学或/和随访研究结果相关联。
共纳入 76 例患者，其中 60 例为男性。病变包括原发性肾肿瘤、复发性肾窝病变、淋巴结和远处转移病变。在 176 个恶性病变中，CT 检出 157 个病变，其中 154 个为真阳性；22 个假阴性病变显示 FDG 摄取异常。CT 扫描的阳性预测值（PPV）、阴性预测值（NPV）、敏感度、特异度和准确度分别为 98.0%、37.1%、87.5%、81.2%和 86.9%。176 个病变均为 PET/CT 阳性，PET/CT 的 PPV、NPV、敏感度、特异度和准确度均为 100%。PET/CT 的特异度和 NPV 均更高（P<.05）。
与 CT 扫描相比，PET/CT 更准确地检测肾细胞癌患者的转移和复发。
