Department of Stem Cell Sciences, Hacettepe University Graduate School of Health Sciences, Sihhiye, Turkey.
Center for Stem Cell Research and Development, Hacettepe University, Sihhiye, Turkey.
Tissue Barriers. 2023 Oct 2;11(4):2131955. doi: 10.1080/21688370.2022.2131955. Epub 2022 Oct 11.
Interstitial cells are present in the environment of stem cells in order to increase stem cell proliferation and differentiation and they are important to increase the efficiency of their transplantation. Telocytes (TCs) play an important role both in the preservation of tissue organ integrity and in the pathophysiology of many diseases, especially cancer. They make homo- or heterocellular contacts to form the structure of 3D network through their telopodes and deliver signaling molecules via a juxtacrine and/or paracrine association by budding shed vesicles into the vascular, nervous and endocrine systems. During this interaction, along with organelles, mRNA, microRNA, long non-coding RNA, and genomic DNA are transferred. This review article not only specifies the properties of TCs and their roles in the tissue organ microenvironment but also gives information about the factors that play a role in the transport of epigenetic information by TCs.
间质细胞存在于干细胞的环境中，以增加干细胞的增殖和分化，这对于提高其移植效率很重要。 间质细胞（TCs）在组织器官完整性的维持和许多疾病（尤其是癌症）的病理生理学中起着重要作用。 它们通过其 telopodes 形成同源或异源细胞接触，形成 3D 网络结构，并通过出芽脱落小泡将信号分子通过旁分泌和/或自分泌关联传递到血管，神经和内分泌系统中。 在这种相互作用中，与细胞器一起，mRNA，microRNA，长非编码 RNA 和基因组 DNA 被转移。 本文综述不仅详细说明了 TCs 的特性及其在组织器官微环境中的作用，还介绍了影响 TCs 传递表观遗传信息的因素。
