Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Division of Histology, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Int J Mol Sci. 2022 May 21;23(10):5769. doi: 10.3390/ijms23105769.
Cardiac interstitium is a complex and dynamic environment, vital for normal cardiac structure and function. Telocytes are active cellular players in regulating main events that feature myocardial homeostasis and orchestrating its involvement in heart pathology. Despite the great amount of data suggesting (microscopically, proteomically, genetically, etc.) the implications of telocytes in the different physiological and reparatory/regenerative processes of the heart, understanding their involvement in realizing the heart's mature cytoarchitecture is still at its dawn. Our scrutiny of the recent literature gave clearer insights into the implications of telocytes in the WNT signaling pathway, but also TGFB and PI3K/AKT pathways that, inter alia, conduct cardiomyocytes differentiation, maturation and final integration into heart adult architecture. These data also strengthen evidence for telocytes as promising candidates for cellular therapies in various heart pathologies.
心脏间质是一个复杂而动态的环境，对维持正常的心脏结构和功能至关重要。 间质细胞是调节心肌稳态的主要事件和协调其参与心脏病理学的活跃的细胞参与者。 尽管有大量数据表明（在显微镜下、蛋白质组学上、遗传学上等）间质细胞在心脏的不同生理和修复/再生过程中的作用，但了解它们在实现心脏成熟细胞结构中的作用仍处于起步阶段。 我们对最新文献的研究更深入地了解了间质细胞在 WNT 信号通路以及 TGFB 和 PI3K/AKT 通路中的作用，这些通路可介导心肌细胞的分化、成熟和最终整合到心脏的成人结构中。 这些数据还为间质细胞作为各种心脏病变的细胞治疗有希望的候选者提供了更多证据。
