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系统性红斑狼疮中的严重肺量计缺陷。支气管肺泡灌洗和镓扫描的可能作用。

Severe spirometric defects in systemic lupus erythematosus. A possible role for bronchoalveolar lavage and gallium scanning.

作者信息

Lin R Y

出版信息

Clin Rheumatol. 1987 Jun;6(2):276-81. doi: 10.1007/BF02201037.

DOI:10.1007/BF02201037
PMID:3621846
Abstract

Two patients with systemic lupus erythematosus (SLE) developed progressive chronic pulmonary disease. Pulmonary bronchoalveolar lavage (BAL) and Gallium-67 scanning were performed and were consistent with alveolitis. In one patient, an open lung biopsy was performed and showed the presence of several immunoreactants as well as interstitial pneumonitis. Although mild pulmonary function abnormalities are common in SLE, some patients such as the two described in this report develop progressive and incapacitating pulmonary impairment. The need for developing standardized indices of pulmonary inflammation such as BAL and gallium scanning for the purposes of diagnosis, prognostication, and monitoring treatment responses in systemic lupus erythematosus is stressed.

摘要

两名系统性红斑狼疮(SLE)患者出现了进行性慢性肺部疾病。进行了肺支气管肺泡灌洗(BAL)和镓-67扫描,结果与肺泡炎相符。其中一名患者进行了开胸肺活检,显示存在多种免疫反应物以及间质性肺炎。虽然轻度肺功能异常在SLE中很常见,但像本报告中描述的两名患者这样的一些患者会出现进行性且使人丧失能力的肺损害。强调了开发标准化肺部炎症指标(如BAL和镓扫描)以用于系统性红斑狼疮的诊断、预后评估和监测治疗反应的必要性。

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本文引用的文献

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PULMONARY DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS.系统性红斑狼疮中的肺功能障碍
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Carbon monoxide diffusing capacity as predictor of outcome in systemic sclerosis.一氧化碳弥散能力作为系统性硬化症预后的预测指标
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