Department of Otolaryngology-Head & Neck Surgery, EpiCURA Hospital, Baudour, Belgium.
Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.
Ear Nose Throat J. 2024 Jun;103(1_suppl):115S-119S. doi: 10.1177/01455613221124773. Epub 2022 Oct 11.
In this paper, we described technique of platelet rich plasma injection into the olfactory cleft in a 22-year-old female with 24-month post-COVID-19 anosmia. The technique starts with the blood extraction and the isolation of PRP through a 10-min centrifugation. The supernatant was injected in nasal regions after a local anesthesia through a 0° rigid optic. Several points of .2-.5 mL were performed in the nasal septum in regard of the head of the middle turbine and in the head of the middle turbine in both sides. The baseline threshold, discrimination, and identification scores were 1, 8, and 0, and the Olfactory Disorder Questionnaire score was 51, respectively. The injection of PRP in olfactory cleft was done without complication and mild pain. The patient perception of recovery of smell sense occurred at 3-week post-injection. From this time, the smell sense progressively improved to the 2-month consultation. At 2-month post-injection, the TDI scores reached 16, 16, and 16 (48), while the Olfactory Disorder Questionnaire was 73. The injection of PRP into the olfactory cleft appears to be a safe and easiness new approach that may improve the recovery of smell sense. Future controlled studies are needed.
本文介绍了一种将富含血小板的血浆（PRP）注射到嗅觉裂的技术，用于治疗一位 24 个月后出现 COVID-19 后嗅觉丧失的 22 岁女性。该技术首先从血液中提取并通过 10 分钟的离心分离 PRP。在局部麻醉下，通过 0°刚性光学镜将上清液注射到鼻腔区域。在鼻中隔的头部以及两侧的中鼻甲头部进行了几个点的注射，每个点注射 0.2-0.5 毫升。基线阈值、辨别和识别分数分别为 1、8 和 0，嗅觉障碍问卷评分分别为 51。PRP 注射到嗅觉裂中没有并发症，仅有轻度疼痛。患者在注射后 3 周开始感觉到嗅觉恢复。从那时起，嗅觉逐渐改善，在 2 个月的咨询时达到最佳。在注射后 2 个月时，TDI 评分为 16、16 和 16（48），而嗅觉障碍问卷评分为 73。将 PRP 注射到嗅觉裂似乎是一种安全且简单的新方法，可能会改善嗅觉恢复。未来需要进行对照研究。
