Vellacott I D, Shroff N E, Pearce M Y, Stratford M E, Akbar F A
Curr Med Res Opin. 1987;10(7):450-6. doi: 10.1185/03007998709112403.
The effect of spironolactone in the alleviation of the symptoms of the premenstrual syndrome was compared with placebo in a double-blind, parallel group controlled study. One tablet daily of 100 mg spironolactone or placebo was given to 63 women from Day 12 of the menstrual cycle until the first day of the next menstrual bleed. This regimen was repeated for two consecutive cycles. Spironolactone was statistically significantly superior in providing relief from bloatedness (p less than 0.001). No statistically significant changes were observed in blood biochemistry of plasma hormone levels of oestradiol, progesterone or prolactin, though an increase in serum aldosterone levels was seen in the spironolactone-treated group. No differences were detected in weight, blood pressure or the incidence and severity of complaints following treatment.
在一项双盲、平行组对照研究中，将螺内酯缓解经前综合征症状的效果与安慰剂进行了比较。从月经周期的第12天开始，每天给63名女性服用1片100毫克的螺内酯或安慰剂，直至下次月经来潮的第一天。该方案连续重复两个周期。在缓解腹胀方面，螺内酯在统计学上具有显著优势（p<0.001）。虽然在螺内酯治疗组中观察到血清醛固酮水平升高，但在血浆雌二醇、孕酮或催乳素的血液生化指标以及血浆激素水平方面未观察到统计学上的显著变化。治疗后在体重、血压或不适的发生率及严重程度方面未检测到差异。
