Wang Y W, Sun X D
Department of Ophthalmology, Affiliated First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
Zhonghua Yan Ke Za Zhi. 2022 Oct 11;58(10):839-842. doi: 10.3760/cma.j.cn112142-20220507-00225.
A large number of commensal bacteria settle in the intestine and play an important role in maintaining normal functions of the intestine, regulating host immunity and metabolism. In recent years, researches have found that intestinal flora can be involved in the occurrence and deterioration of various extraintestinal diseases. Ophthalmic diseases such as uveitis, age-related macular degeneration, and glaucoma are also affected by the intestinal flora. The intestinal flora and its metabolites, under different circumstances, can change the body's immune homeostasis or regulate multiple metabolic pathways, induce autoimmune responses in the eyes and promote chronic inflammation. This article reviews the relationship between intestinal flora and ophthalmic diseases to provide new research ideas for the pathogenesis and intervention of various ophthalmic diseases.
大量共生细菌定居于肠道，在维持肠道正常功能、调节宿主免疫和代谢方面发挥着重要作用。近年来，研究发现肠道菌群可参与多种肠外疾病的发生和恶化。葡萄膜炎、年龄相关性黄斑变性和青光眼等眼科疾病也受到肠道菌群的影响。在不同情况下，肠道菌群及其代谢产物可改变机体免疫稳态或调节多种代谢途径，诱发眼部自身免疫反应并促进慢性炎症。本文综述肠道菌群与眼科疾病的关系，为各种眼科疾病的发病机制和干预提供新的研究思路。
