Berk T, Cohen Z, McLeod R S, Cullen J B
Dis Colon Rectum. 1987 Aug;30(8):588-90. doi: 10.1007/BF02554803.
The histopathology of 304 patients registered in the Canadian Familial Polyposis Registry (CFPR) with a diagnosis of supposed adenomatous polyposis (AP) was reviewed. The diagnosis was changed in 17 (5.6 percent) of these patients. Group 1 consisted of nine patients who had adenocarcinomas plus multiple tubular adenomas (seven) or metaplastic polyps (two). Eight patients who had no colon cancer comprised Group 2. In these patients, the diagnosis was changed to lymphoid polyposis (2), metaplastic polyps (3), isolated adenomas (2), or juvenile polyposis (1). All 17 patients had had previous colonic resections. Following the change in diagnosis, this treatment was considered inappropriate in 11 patients. Treatment, prognosis, and follow-up of patients and affected family members depend on the type of polyposis syndrome diagnosed. Correct histologic assessment of polyps prior to initial surgery is essential.
对加拿大家族性息肉病登记处（CFPR）登记的304例诊断为疑似腺瘤性息肉病（AP）的患者的组织病理学进行了回顾。其中17例（5.6%）患者的诊断被更改。第1组包括9例患有腺癌加多个管状腺瘤（7例）或化生息肉（2例）的患者。第2组包括8例无结肠癌的患者。在这些患者中，诊断被更改为淋巴样息肉病（2例）、化生息肉（3例）、孤立性腺瘤（2例）或幼年性息肉病（1例）。所有17例患者此前均接受过结肠切除术。诊断更改后，11例患者的这种治疗被认为不合适。患者及其受影响家庭成员的治疗、预后和随访取决于所诊断的息肉病综合征类型。初次手术前对息肉进行正确的组织学评估至关重要。
