3Bio Team, Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199 Université de Strasbourg/CNRS, Faculté de Pharmacie, Illkirch, F-67401 Cedex, France.
Équipe de chimie et neurobiologie moléculaire, Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199 Université de Strasbourg/CNRS, Faculté de Pharmacie, Illkirch, F-67401 Cedex, France.
Adv Healthc Mater. 2023 Jan;12(2):e2201474. doi: 10.1002/adhm.202201474. Epub 2022 Oct 26.
Photolytic reactions allow the optical control of the liberation of biological effectors by photolabile protecting groups. The development of versatile technologies enabling the use of deep-red or NIR light excitation still represents a challenging issue, in particular for light-induced drug release (e.g., light-induced prodrug activation). Here, light-sensitive biocompatible lipid nanocapsules able to liberate an antitumoral drug through photolysis are presented. It is demonstrated that original photon upconverting nanoparticles (LNC-UCs) chemically conjugated to a coumarin-based photocleavable linker can quantitatively and efficiently release a drug by upconversion luminescence-assisted photolysis using a deep-red excitation wavelength. In addition, it is also able to demonstrate that such nanoparticles are stable in the dark, without any drug leakage in the absence of light. These findings open new avenues to specifically liberate diverse drugs using deep-red or NIR excitations for future therapeutic applications in nanomedicine.
光解反应允许通过光不稳定保护基团来控制生物效应物的释放。开发多功能技术以实现深红光或近红外光激发仍然是一个具有挑战性的问题，特别是对于光诱导药物释放（例如，光诱导前药激活）。在这里，介绍了能够通过光解释放抗肿瘤药物的光敏感生物相容性脂质纳米胶囊。结果表明，化学连接到香豆素基光可裂解连接子上的原始光子上转换纳米颗粒（LNC-UCs）可以通过上转换发光辅助光解，使用深红光激发波长定量且有效地释放药物。此外，还能够证明在没有光的情况下，这些纳米粒子在黑暗中是稳定的，没有任何药物泄漏。这些发现为使用深红光或近红外光激发来专门释放各种药物开辟了新途径，为纳米医学中的未来治疗应用提供了可能。
