实验性胸腔积液对抗生素抗菌活性的增强作用。
Enhancement of antibiotic antibacterial activity by experimental pleural exudates.
作者信息
Miglioli P A, Bertazzoni-Minelli E, Berti T
出版信息
Drugs Exp Clin Res. 1987;13(3):161-6.
The aim of this research was to study the synergistic effect of experimental pleural exudates and antimicrobial drugs on various microorganisms. The antibacterial activity of different pleural exudates alone and in the presence of sub-MIC amounts of antibiotics was studied by a continuous recording turbidimetric method. Synergistic action between the antibiotics and the exudates was demonstrated. This phenomenon can be explained by the presence of heat-labile substances that themselves possess only slight antibacterial activity but are able to increase the effect of sub-MIC antibacterial drugs.
本研究的目的是研究实验性胸腔积液与抗菌药物对各种微生物的协同作用。采用连续记录比浊法研究了不同胸腔积液单独及在低于最低抑菌浓度（sub-MIC）量抗生素存在时的抗菌活性。结果表明抗生素与胸腔积液之间存在协同作用。这种现象可以用存在热不稳定物质来解释，这些物质本身仅具有轻微的抗菌活性，但能够增强低于最低抑菌浓度抗菌药物的效果。
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